Karem A. Court   Hiroto Hatakeyama   Sherry Y. Wu   Mangala S. Lingegowda   Cristian Rodriguez-Aguayo   Gabriel Lopez-Berestein   Lee Ju-Seog   Carlos Rinaldi   Eduardo J. Juan   Anil K. Sood   Madeline Torres-Lugo   
MOLECULAR CANCER THERAPEUTICS 16(5) 966-976 2017年5月 [査読有り]
Hyperthermia has been investigated as a potential treatment for cancer. However, specificity in hyperthermia application remains a significant challenge. Magnetic fluid hyperthermia (MFH) may be an alternative to surpass such a challenge, but impl...
Yan Huang   Lenard M. Lichtenberger   Morgan Taylor   Justin N. Bottsford-Miller   Monika Haemmerle   Michael J. Wagner   Yasmin Lyons   Sunila Pradeep   Wei Hu   Rebecca A. Previs   Jean M. Hansen   Dexing Fang   Piotr L. Dorniak   Justyna Filant   Elizabeth J. Dial   Fangrong Shen   Hiroto Hatakeyama   Anil K. Sood   
MOLECULAR CANCER THERAPEUTICS 15(12) 2894-2904 2016年12月 [査読有り]
To determine the efficacy of a novel and safer (for gastrointestinal tract) aspirin (aspirin-PC) in preclinical models of ovarian cancer, in vitro dose-response studies were performed to compare the growth-inhibitory effect of aspirin-PC versus as...
Hiroto Hatakeyama   Sherry Y. Wu   Yasmin A. Lyons   Sunila Pradeep   Wanqin Wang   Qian Huang   Karem A. Court   Tao Liu   Song Nie   Cristian Rodriguez-Aguayo   Fangrong Shen   Yan Huang   Takeshi Hisamatsu   Takashi Mitamura   Nicholas Jennings   Jeajun Shim   Piotr L. Dorniak   Lingegowda S. Mangala   Marco Petrillo   Vladislav A. Petyuk   Athena A. Schepmoes   Anil K. Shukla   Madeline Torres-Lugo   Ju-Seog Lee   Karin D. Rodland   Anna Fagotti   Gabriel Lopez-Berestein   Chun Li   Anil K. Sood   
CELL REPORTS 17(6) 1621-1631 2016年11月 [査読有り]
Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have divers...
Golam Kibria   Hiroto Hatakeyama   Yusuke Sato   Hideyoshi Harashima   
INTERNATIONAL JOURNAL OF PHARMACEUTICS 509(1-2) 178-187 2016年7月 [査読有り]
The PEGylated liposomal (PEG-LP) Doxorubicin, PEG-LP (DOX), with a diameter of around 100 nm, accumulates in tumors via the enhanced permeability and retention (EPR) effect, and is used clinically for the treatment of several types of cancer. Howe...
Khalil IA, Hatakeyama H, Nakamura T, Harashima H(担当:分担執筆, 範囲:A Multifunctional Envelope-type Nano Device for Cancer Therapy)
Springer 2019年 (ISBN:9784431568803) [査読有り]
This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophys...