Sherry Y. Wu   Rajesha Rupaimoole   Fangrong Shen   Sunila Pradeep   Chad V. Pecot   Cristina Ivan   Archana S. Nagaraja   Kshipra M. Gharpure   Elizabeth Pham   Hiroto Hatakeyama   Michael H. McGuire   Monika Haemmerle   Viviana Vidal-Anaya   Courtney Olsen   Cristian Rodriguez-Aguayo   Justyna Filant   Ehsan A. Ehsanipour   Shelley M. Herbrich   Sourindra N. Maiti   Li Huang   Ji Hoon Kim   Xinna Zhang   Hee-Dong Han   Guillermo N. Armaiz-Pena   Elena G. Seviour   Sue Tucker   Min Zhang   Da Yang   Laurence J. N. Cooper   Rouba Ali-Fehmi   Menashe Bar-Eli   Ju-Seog Lee   Prahlad T. Ram   Keith A. Baggerly   Gabriel Lopez-Berestein   Mien-Chie Hung   Anil K. Sood   
NATURE COMMUNICATIONS 7 2016年4月 [査読有り]
A deeper mechanistic understanding of tumour angiogenesis regulation is needed to improve current anti-angiogenic therapies. Here we present evidence from systems-based miRNA analyses of large-scale patient data sets along with in vitro and in viv...
Yusuke Sato   Hiroto Hatakeyama   Mamoru Hyodo   Hideyoshi Harashima   
MOLECULAR THERAPY 24(4) 788-795 2016年4月 [査読有り]
While a variety of short interfering RNA (siRNA) delivery compounds have been developed, a deep understanding of the key parameters that determine the quality of siRNA delivery are not known with certainty. Therefore, an understanding of the facto...
Wu SY   Rupaimoole R   Shen F   Pradeep S   Pecot CV   Ivan C   Nagaraja AS   Gharpure KM   Pham E   Hatakeyama H   McGuire MH   Haemmerle M   Vidal-Anaya V   Olsen C   Rodriguez-Aguayo C   Filant J   Ehsanipour EA   Herbrich SM   Maiti SN   Huang L   Kim JH   Zhang X   Han HD   Armaiz-Pena GN   Seviour EG   Tucker S   Zhang M   Yang D   Cooper LJ   Ali-Fehmi R   Bar-Eli M   Lee JS   Ram PT   Baggerly KA   Lopez-Berestein G   Hung MC   Sood AK   
JOURNAL OF HEPATOLOGY 64(3) 547-555 2016年3月 [査読有り]
Background & Aims: Antiviral agents including entecavir (ETV) suppress the replication of the hepatitis B virus (HBV) genome in human hepatocytes, but they do not reduce the abundance of viral proteins. The present study focused on effectively red...
JOURNAL OF CONTROLLED RELEASE 225 183-191 2016年3月 [査読有り]
Applying small interfering RNA (siRNA) to dendritic cell (DC) based therapy represents a potential candidate for cancer immunotherapy. However, delivering siRNA to DCs is a challenging issue for non-viral vectors. To date, only viral vectors have ...
Khalil IA, Hatakeyama H, Nakamura T, Harashima H(担当:分担執筆, 範囲:A Multifunctional Envelope-type Nano Device for Cancer Therapy)
Springer 2019年 (ISBN:9784431568803) [査読有り]
This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophys...