中司寛子

研究者氏名	中司寛子

URL
所属	千葉大学
部署	大学院薬学研究院免疫微生物学研究室
職名	准教授
学位	博士（薬学）(東京理科大学)
J-Global ID	201901001414684418

研究分野

ライフサイエンス / 免疫学 /

経歴

2023年8月

現在

文部科学省研究振興局学術調査官

2022年4月

現在

千葉大学大学院薬学研究院免疫微生物学研究室准教授

2017年7月

2022年3月

慶應義塾大学医学部微生物学・免疫学教室助教

2014年4月

2017年6月

慶應義塾大学医学部微生物学・免疫学教室特任助教

2011年4月

2014年5月

National Institute of Dental and Craniofacial Research, National Institutes of Health (USA) Visiting Fellow

論文

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Inhibition of Nr4a receptors enhances antitumor immunity by breaking treg-mediated immune tolerance

Sana Hibino Shunsuke Chikuma Taisuke Kondo Minako Ito Hiroko Nakatsukasa Setsuko Omata-Mise Akihiko Yoshimura

Cancer Research 78(11) 3027-3040 2018年6月 [査読有り]

Enhanced infiltration of regulatory T cells (Treg) into tumor tissue is detrimental to patients with cancer and is closely associated with poor prognosis as they create an immunosuppressive state that suppresses antitumor immune responses. Therefo...

Generation of allo-antigen-specific induced Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model

Hidenori Kasahara Taisuke Kondo Hiroko Nakatsukasa Shunsuke Chikuma Minako Ito Makoto Ando Yutaka Kurebayashi Takashi Sekiya Taketo Yamada Shinichiro Okamoto Akihiko Yoshimura

INTERNATIONAL IMMUNOLOGY 29(10) 457-469 2017年10月 [査読有り]

Antigen-specific regulatory T cells (Tregs) possess the potential to reduce excess immune responses in autoimmune diseases, allergy, rejection after organ transplantation and graft-versus-host disease (GVHD) following hematopoietic stem cell trans...

Induction and maintenance of regulatory T cells by transcription factors and epigenetic modifications

Mana Iizuka-Koga Hiroko Nakatsukasa Minako Ito Takashi Akanuma Qianjin Lu Akihiko Yoshimura

JOURNAL OF AUTOIMMUNITY 83 113-121 2017年9月 [査読有り]

Regulatory T cells (Tregs) are an essential cell subset for the maintenance of immune homeostasis. Foxp3 (Forkhead box P3) is the Treg master gene which is essential for immune suppressing activity. In addition, Tregs are characterized by a distin...

D-mannose induces regulatory T cells and suppresses immunopathology

Dunfang Zhang Cheryl Chia Xue Jiao Wenwen Jin Shimpei Kasagi Ruiqing Wu Joanne E. Konkel Hiroko Nakatsukasa Peter Zanvit Nathan Goldberg Qianming Chen Lingyun Sun Zi-Jiang Chen WanJun Chen

NATURE MEDICINE 23(9) 1036-+ 2017年9月 [査読有り]

D-mannose, a C-2 epimer of glucose, exists naturally in many plants and fruits, and is found in human blood at concentrations less than one-fiftieth of that of glucose. However, although the roles of glucose in T cell metabolism, diabetes and obes...

Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation

Kazue Someya Hiroko Nakatsukasa Minako Ito Taisuke Kondo Kenn-ichi Tateda Takashi Akanuma Ikuko Koya Tsukasa Sanosaka Jun Kohyama Yu-ichi Tsukada Takeji Takamura-Enya Akihiko Yoshimura

INTERNATIONAL IMMUNOLOGY 29(8) 365-375 2017年8月 [査読有り]

Since induced regulatory T cells (iTregs) can be produced in a large quantity in vitro, these cells are expected to be clinically useful to induce immunological tolerance in various immunological diseases. Foxp3 (Forkhead box P3) expression in iTr...