中司寛子

研究者氏名	中司寛子

URL
所属	千葉大学
部署	大学院薬学研究院免疫微生物学研究室
職名	准教授
学位	博士（薬学）(東京理科大学)
J-Global ID	201901001414684418

研究分野

ライフサイエンス / 免疫学 /

経歴

2023年8月

現在

文部科学省研究振興局学術調査官

2022年4月

現在

千葉大学大学院薬学研究院免疫微生物学研究室准教授

2017年7月

2022年3月

慶應義塾大学医学部微生物学・免疫学教室助教

2014年4月

2017年6月

慶應義塾大学医学部微生物学・免疫学教室特任助教

2011年4月

2014年5月

National Institute of Dental and Craniofacial Research, National Institutes of Health (USA) Visiting Fellow

論文

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SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions

Reiko Takahashi Hiroko Nakatsukasa Shunichi Shiozawa Akihiko Yoshimura

JOURNAL OF IMMUNOLOGY 199(1) 149-158 2017年7月 [査読有り]

We previously showed that regulatory T cells (Tregs) from T cell-specific Socs1-deficient mice (Socs1(fl/fl) Lck-Cre(+) mice) easily convert into Th1- or Th17-like cells (ex-Tregs), which lose Foxp3 expression and suppressive functions in vivo. Be...

Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells

Masahiro Okada Mitsuhiro Kanamori Kazue Someya Hiroko Nakatsukasa Akihiko Yoshimura

EPIGENETICS & CHROMATIN 10 24-24 2017年5月 [査読有り]

Background: Epigenome editing is expected to manipulate transcription and cell fates and to elucidate the gene expression mechanisms in various cell types. For functional epigenome editing, assessing the chromatin context-dependent activity of art...

Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

Taisuke Kondo Rimpei Morita Yuumi Okuzono Hiroko Nakatsukasa Takashi Sekiya Shunsuke Chikuma Takashi Shichita Mitsuhiro Kanamori Masato Kubo Keiko Koga Takahiro Miyazaki Yoshiaki Kassai Akihiko Yoshimura

NATURE COMMUNICATIONS 8 15338-15338 2017年5月 [査読有り]

Adoptive T-cell immunotherapy is a promising approach to cancer therapy. Stem cell memory T (T-SCM) cells have been proposed as a class of long-lived and highly proliferative memory T cells. CD8(+) TSCM cells can be generated in vitro from naive C...

Role of ATP as a Key Signaling Molecule Mediating Radiation-Induced Biological Effects

Shuji Kojima Yasuhiro Ohshima Hiroko Nakatsukasa Mitsutoshi Tsukimoto

DOSE-RESPONSE 15(1) 1559325817690638 2017年3月 [査読有り]

Adenosine triphosphate (ATP) serves as a signaling molecule for adaptive responses to a variety of cytotoxic agents and plays an important role in mediating the radiation stress-induced responses that serve to mitigate or repair the injurious effe...

Induced Regulatory T Cells: Their Development, Stability, and Applications

Mitsuhiro Kanamori Hiroko Nakatsukasa Masahiro Okada Qianjin Lu Akihiko Yoshimura

TRENDS IN IMMUNOLOGY 37(11) 803-811 2016年11月 [査読有り]

Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many facets of immune systems. The transcription factor Foxp3 has been characterized as a master regulator of Tregs, and is induced during their thymic de...