研究者氏名	中司寛子

URL
所属	千葉大学
部署	大学院薬学研究院免疫微生物学研究室
職名	准教授
学位	博士（薬学）(東京理科大学)
J-Global ID	201901001414684418

研究分野

ライフサイエンス / 免疫学 /

経歴

2023年8月

現在

文部科学省研究振興局学術調査官

2022年4月

現在

千葉大学大学院薬学研究院免疫微生物学研究室准教授

2017年7月

2022年3月

慶應義塾大学医学部微生物学・免疫学教室助教

2014年4月

2017年6月

慶應義塾大学医学部微生物学・免疫学教室特任助教

2011年4月

2014年5月

National Institute of Dental and Craniofacial Research, National Institutes of Health (USA) Visiting Fellow

論文

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CPT-11 mitigates autoimmune diseases by suppressing effector T cells without affecting long-term anti-tumor immunity.

Hantian Liang Xinzou Fan Hao Cheng Xiao Ma Yutong Sun Fang Nan Jingyang Zhou Panyin Shu Wei Zhang Fengqiong Zuo Hiroko Nakatsukasa Dunfang Zhang

Cell death discovery 10(1) 218-218 2024年5月

The incidence of autoimmune diseases has significantly increased over the past 20 years. Excessive host immunoreactions and disordered immunoregulation are at the core of the pathogenesis of autoimmune diseases. The traditional anti-tumor chemothe...

Prevention of experimental autoimmune encephalomyelitis by targeting 6-sulfo sialyl Lewis X glycans involved in lymphocyte homing.

Qianqian Liu Wei Xiong Sachiyo Obara Hirohito Abo Hiroko Nakatsukasa Hiroto Kawashima

International immunology 36(6) 303-316 2024年4月

Abstract

Lymphocyte homing to peripheral lymph nodes (PLN) is critical for immune surveillance. However, autoimmune diseases such as multiple sclerosis (MS) can occur due to excessive immune responses in the PLN. Here we show that 6-sulfo sialyl...

Sialyl Lewis X Defines an Activated and Functional Regulatory T Cell Subpopulation in Mice.

Kanae Ohishi Asaki Ishikura Shogo Nishida Hirohito Abo Hiroko Nakatsukasa Hiroto Kawashima

Journal of immunology (Baltimore, Md. : 1950) 2024年4月

Attempts have been made to elucidate the functional markers of regulatory T cells (Tregs), CD4+Foxp3+ T cells with an immunosuppressive function. Sialyl Lewis X (sLex), a tetrasaccharide Ag, is involved in leukocyte trafficking as selectin ligands...

Editorial: Oral mucosal immunity: homeostasis and inflammation.

Dunfang Zhang Junji Xu Zhi Wang Hiroko Nakatsukasa

Frontiers in immunology 14 1214926-1214926 2023年

Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.

Sang-A Park Yun-Ji Lim Wai Lim Ku Dunfang Zhang Kairong Cui Liu-Ya Tang Cheryl Chia Peter Zanvit Zuojia Chen Wenwen Jin Dandan Wang Junji Xu Ousheng Liu Fu Wang Alexander Cain Nancy Guo Hiroko Nakatsukasa Chuan Wu Ying E Zhang Keji Zhao WanJun Chen

Nature communications 13(1) 6069-6069 2022年10月

Interleukin-9 (IL-9)-producing CD4+ T helper cells (Th9) have been implicated in allergy/asthma and anti-tumor immunity, yet molecular insights on their differentiation from activated T cells, driven by IL-4 and transforming growth factor-beta (TG...