日本薬物動態学会, DMPK論文賞1st place,Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6柴田侑裕 爲本雄太 Sheelendra Pratap Singh 吉友葵 保月静香 佐藤洋美 樋坂章博
International journal of molecular sciences 22(16) 2021年8月 [査読有り]
The second messenger 2'3'-cyclic-GMP-AMP (cGAMP) is thought to be transmitted from brain carcinomas to astrocytes via gap junctions, which functions to promote metastasis in the brain parenchyma. In the current study, we established a method to in...
International journal of molecular sciences 22(14) 2021年7月
The role of astrocytes in the periphery of metastatic brain tumors is unclear. Since astrocytes regulate central nervous metabolism, we hypothesized that changes in astrocytes induced by contact with cancer cells would appear in the metabolome of ...
CPT: pharmacometrics & systems pharmacology 2021年7月 [査読有り]
To characterize and compare various medicines for chronic heart failure (CHF), changes in circulatory physiological parameter during pharmacotherapy were investigated by a model-based meta-analysis (MBMA) of circulatory physiology. The clinical da...
Drug metabolism and disposition: the biological fate of chemicals 2021年5月 [査読有り]
Precise prediction of drug absorption is key to the success of new drug development and efficacious pharmacotherapy. In this study, we developed a new absorption model, the advanced translocation model (ATOM), by extending our previous model, the ...