日本薬物動態学会, DMPK論文賞1st place,Plausible drug interaction between cyclophosphamide and voriconazole via inhibition of CYP2B6柴田侑裕 爲本雄太 Sheelendra Pratap Singh 吉友葵 保月静香 佐藤洋美 樋坂章博
JOURNAL OF PHARMACEUTICAL SCIENCES 106(9) 2771-2779 2017年9月 [査読有り]
In this study, intestinal drug-drug interactions (DDIs) for substrate drugs of P-glycoprotein were simulated extensively using the extended Q(Gut) model and translocation model to explore the determinants of DDI. The results of analyses using both...
Sunitinib (SU) is a small molecule that inhibits the receptor tyrosine kinase (RTK) signaling pathway, and has been clinically used to treat advanced renal cell carcinoma (RCC). However, SU is not always effective as RCC is a highly chemoresistant...
JOURNAL OF PHARMACOLOGICAL SCIENCES 134(2) 101-107 2017年6月 [査読有り]
The constituent protein of gap junctions, connexin (Cx), interacts with various proteins via its C-terminus region, including kinases, cell-adhesion proteins, and a pro-apoptotic protein, Bax. This molecular interaction may affect expression and f...
Hiromi Sato   Asami Funaki   Yuki Kimura   Mai Sumitomo   Hiroya Yoshida   Hideki Fukata   Koichi Ueno   
NUTRITION RESEARCH 36(7) 731-741 2016年7月 [査読有り]
In this study, we examined the cell differentiation effect of an ethanol extract of Cyclolepis genistoides D. Don, a herbaceous perennial belonging to the family Asteraceae (vernacular name: palo azul). Palo azul has numerous physiological effects...