Takayoshi Arai   Katsuya Sato   Ayu Nakamura   Hiroki Makino   Hyuma Masu   
Scientific Reports 8(1) 2018年12月 [査読有り]
A phosphoiminoBINOL ligand was designed to form a dinuclear metal complex that could hold a malononitrile molecule. The dinuclear bis(phosphoimino)binaphthoxy-Pd2(OAc)2 complex catalyzed a double Mannich reaction of N-Boc-imines with malononitrile...
Ko Urushibara   Yann Ferrand   Zhiwei Liu   Hyuma Masu   Vojislava Pophristic   Aya Tanatani   Ivan Huc   
Angewandte Chemie - International Edition 57(26) 7888-7892 2018年6月 [査読有り]
Macrocyclization of a stable two-turn helical aromatic pentamide, that is, an object with diverging ends that are not prone to cyclization, was made possible by the transient introduction of disruptors of helicity in the form of acid-labile dimeth...
Journal of Organic Chemistry 83(8) 4606-4617 2018年4月 [査読有り]
N-Alkylbenzanilides generally exist in cis conformation both in the crystalline state and in various solvents, and this cis conformational preference can be utilized to construct dynamic helical oligoamides. Here, we synthesized the pyrrole-contai...
The morphology and stability of amorphous nanoparticles of glibenclamide (GLB) prepared by the antisolvent method using different methods of adding hypromellose (HPMC) were evaluated. Nano-A was prepared by the injection of a dimethyl sulfoxide (D...