小林和史

研究者氏名	小林和史
	コバヤシカズフミ
URL
所属	千葉大学
部署	大学院医学研究院　消化器内科学
職名
学位	医学博士(千葉大学)
科研費研究者番号	40836615
J-Global ID	202101015962864350

論文

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Successful Identification of a Novel Therapeutic Compound for Hepatocellular Carcinoma Through Screening of ADAM9 Inhibitors.

Keita Ogawa Tetsuhiro Chiba Masato Nakamura Jun Arai Jiaqi Zhang Yaojia Ma N A Qiang Junjie Ao Sae Yumita Takamasa Ishino Motoyasu Kan Terunao Iwanaga Miyuki Nakagawa Kisako Fujiwara Takafumi Sakuma Hiroaki Kanzaki Keisuke Koroki Yuko Kusakabe Kazufumi Kobayashi Naoya Kanogawa Soichiro Kiyono Takayuki Kondo Ryo Nakagawa Sadahisa Ogasawara Ryosuke Muroyama Shingo Nakamoto Tatsuo Kanda Hitoshi Maruyama Jun Kato Shoji Matsumoto Takayoshi Arai Shinichiro Motohashi Naoya Kato

Anticancer research 43(3) 1043-1052 2023年3月

BACKGROUND/AIM: MHC-class I-related chain A (MICA) functions as a ligand for natural killer group D, an activating receptor on natural killer (NK) cells, and its expression correlates with the carcinogenesis and progression of hepatocellular carci...

【肝胆膵がん治療の進歩2023】肝細胞がん切除不能例に対する免疫療法

弓田冴小林和史神崎洋彰興梠慧輔兒島隆太井上将法中村昌人清野宗一郎叶川直哉近藤孝行中川良小笠原定久中本晋吾加藤直也

腫瘍内科 31(2) 146-152 2023年2月

Miglustat, a glucosylceramide synthase inhibitor, mitigates liver fibrosis through TGF-β/Smad pathway suppression in hepatic stellate cells.

Terunao Iwanaga Tetsuhiro Chiba Masato Nakamura Tatsuya Kaneko Junjie Ao Na Qiang Yaojia Ma Jiaqi Zhang Tadayoshi Kogure Sae Yumita Takamasa Ishino Keita Ogawa Motoyasu Kan Miyuki Nakagawa Kisako Fujiwara Naoto Fujita Takafumi Sakuma Hiroaki Kanzaki Keisuke Koroki Yuko Kusakabe Masanori Inoue Kazufumi Kobayashi Naoya Kanogawa Soichiro Kiyono Takayuki Kondo Ryo Nakagawa Sadahisa Ogasawara Shingo Nakamoto Ryosuke Muroyama Jun Kato Tatsuo Kanda Hitoshi Maruyama Naoya Mimura Takuya Honda Toshihiko Murayama Hiroyuki Nakamura Naoya Kato

Biochemical and biophysical research communications 642 192-200 2023年1月

Transforming growth factor (TGF)-β/Smad pathway is implicated in the pathogenesis of liver fibrosis, a condition characterized by excessive deposition of extracellular matrix (ECM) proteins such as collagen in response to chronic inflammation. It ...

The efficacy of contrast-enhanced computed tomography on the management of gastroesophageal varices in patients with hepatocellular carcinoma

Takayuki Kondo Kisako Fujiwara Miyuki Nakagawa Hidemi Unozawa Terunao Iwanaga Takafumi Sakuma Naoto Fujita Keisuke Koroki Hiroaki Kanzaki Kazufumi Kobayashi Soichiro Kiyono Masato Nakamura Naoya Kanogawa Tomoko Saito Sadahisa Ogasawara Eiichiro Suzuki Yoshihiko Ooka Shingo Nakamoto Tetsuhiro Chiba Makoto Arai Jun Kato Naoya Kato

Scientific Reports 12(1) 2022年12月

Abstract

The screening of gastroesophageal varices (GEV) is critical in hepatocellular carcinoma (HCC) management. Contrast-enhanced computed tomography (CECT) is often performed in patients with HCC. Therefore, this study aimed to examine the us...

Clinical effects and emerging issues of atezolizumab plus bevacizumab in patients with advanced hepatocellular carcinoma from Japanese real-world practice.

Miyuki Nakagawa Masanori Inoue Sadahisa Ogasawara Susumu Maruta Tomomi Okubo Norio Itokawa Yotaro Iino Masamichi Obu Yuki Haga Atsuyoshi Seki Yasuharu Kikuchi Tadayoshi Kogure Sae Yumita Takamasa Ishino Keita Ogawa Kisako Fujiwara Terunao Iwanaga Naoto Fujita Takafumi Sakuma Ryuta Kojima Hiroaki Kanzaki Keisuke Koroki Takashi Taida Kazufumi Kobayashi Soichiro Kiyono Masato Nakamura Naoya Kanogawa Takayuki Kondo Ryo Nakagawa Shingo Nakamoto Ryosuke Muroyama Tetsuhiro Chiba Ei Itobayashi Masanori Atsukawa Yoshihiro Koma Ryosaku Azemoto Kenji Ito Hideaki Mizumoto Masami Shinozaki Jun Kato Naoya Kato

Cancer 129(4) 590-599 2022年11月

BACKGROUND: Although the efficacy of atezolizumab has been demonstrated in randomized controlled trials, its long-term efficacy and association with adverse events in real-world practice are unknown. This study was designed to shed light on these ...