Amorphous drug nanoparticles usually exhibit low storage stability. A comprehensive understanding of the molecular states and physicochemical properties of the product is indispensable for designing stable formulations. In the present study, an am...
Physical Chemistry Chemical Physics 24(43) 26575-26582 2022年
Despite being an LCST system, the NMR results indicate that the number of ionic liquid ions interacting with the solute polymer increases even at temperatures approaching the separation line.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 168 106038-106038 2022年1月
Phytosterol (PSE)/γ-cyclodextrin (γ-CD) microparticles have a capsule-like structure, wherein the hydrophobic PSE core is surrounded by outer layers of the hydrophilic PSE/γ-CD inclusion complex crystal. The microparticles could mask the undesirab...
International journal of pharmaceutics 610 121210-121210 2021年12月
The present study focuses on the effect of the preparation temperature on the physicochemical properties of amorphous drug nanoparticles to clarify their formation mechanism. Amorphous glibenclamide (GLB) nanoparticles were prepared at 4-40 °C usi...