To meet the energetic requirements associated with activation, proliferation and survival, T cells switch their metabolic signatures from energetically quiescent to activated. However, little is known about the role of metabolic pathway controllin...
Ryo Koyama-Nasu Motoko Y Kimura Masahiro Kiuchi Ami Aoki Yangsong Wang Yukiyoshi Mita Ichita Hasegawa Yukihiro Endo Atsushi Onodera Kiyoshi Hirahara Shinichiro Motohashi Toshinori Nakayama
Cancer immunology research May 2023 [Refereed]
Tumor-specific CD8+ T cells play a pivotal role in anti-tumor immunity and are a key target of immunotherapeutic approaches. Intratumoral CD8+ T cells are heterogeneous; Tcf1+ stem-like CD8+ T cells give rise to their cytotoxic progeny - Tim-3+ te...
Proceedings of the National Academy of Sciences of the United States of America 119(33) e2203437119 Aug 2022 [Refereed]
The mortality of coronavirus disease 2019 (COVID-19) is strongly correlated with pulmonary vascular pathology accompanied by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-triggered immune dysregulation and aberrant activat...
Journal of Clinical Medicine 11(14) Jul 2022 [Refereed]
Regarding vascularized lymph node transfer (VLNT) for lymphedema, partial blood flow impairment in transferred lymph node (LN) flaps may adversely affect the therapeutic results. We investigated the clinical and histological effects of partial blo...
Self-referential immune perceptionJapan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A)
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