CD69 has been known as an early activation marker of lymphocytes; whereas, recent studies demonstrate that CD69 also has critical functions in immune responses. Early studies using human samples revealed the involvement of CD69 in various inflamma...
Motoko Y. Kimura Julien Thomas Xuguang Tai Terry I. Guinter Miho Shinzawa Ruth Etzensperger Zhenhu Li Paul Love Toshinori Nakayama Alfred Singer
NATURE IMMUNOLOGY 17(12) 1415-1423 Dec 2016 [Refereed]
Major histocompatibility complex class I (MHC I) positive selection of CD8(+) T cells in the thymus requires that T cell antigen receptor (TCR) signaling end in time for cytokines to induce Runx3d, the CD8-lineage transcription factor. We examined...
Leonid A. Pobezinsky Ruth Etzensperger Susanna Jeurling Amala Alag Tejas Kadakia Tom M. McCaughtry Motoko Y. Kimura Susan O. Sharrow Terry I. Guinter Lionel Feigenbaum Alfred Singer
NATURE IMMUNOLOGY 16(5) 517-U234 May 2015 [Refereed]
Lethal-7 (let-7) microRNAs (miRNAs) are the most abundant miRNAs in the genome, but their role in developing thymocytes is unclear. We found that let-7 miRNAs targeted Zbtb16 mRNA, which encodes the lineage-specific transcription factor PLZF, to p...
Self-referential immune perceptionJapan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A)
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