大学院医学研究院

Research Interests

免疫学 Immunology 細胞生物学 Cell Biology 分子生物学 Molecular Biology ,Immunology Cell Biology Molecular Biology

Research Areas

Life sciences / Immunology /

Research History

12 >

Apr 2021

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Today

Chiba University

Jan 2016

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Mar 2021

Chiba University Graduate School of Medicine

Jan 2014

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Dec 2015

Chiba University

Apr 2011

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Dec 2013

National Cancer Institue/ NIH

Apr 2006

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Mar 2011

米国国立癌研究所 Postdoctoral Fellow

Committee Memberships

2016

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Today

Kyoto T Cell Conference(KTCC) 運営委員

2016

-

Today

日本免疫学会評議員

2010

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2011

米国国立衛生研究所 Immunology Interest Group (*IIG) Steering Committee A postdoctoral Fellow representative

Awards

Jun 2017

千葉医学会, 第9回（２０１７年度）千葉医学会賞
木村元子

Feb 2016

第45回日本免疫学会総会・学術集会, ベストプレゼンテーション賞
木村元子

Dec 2002

第32回日本免疫学会総会・学術集会, Melchers' Travel Award
木村元子

Papers

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ACC1-mediated fatty acid biosynthesis intrinsically controls thymic iNKT cell development.

Toshio Kanno Keisuke Miyako Takeru Endo Satoru Yokoyama Hikari K Asou Kazuko Yamada Osamu Ohara Toshinori Nakayama Motoko Y Kimura Yusuke Endo

International immunology Dec 2023

To meet the energetic requirements associated with activation, proliferation and survival, T cells switch their metabolic signatures from energetically quiescent to activated. However, little is known about the role of metabolic pathway controllin...

Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases

Atsushi Onodera Kota Kokubo Mikiko Okano Miki Onoue Masahiro Kiuchi Chiaki Iwamura Tomohisa Iinuma Motoko Y. Kimura Nobuyuki Ebihara Toyoyuki Hanazawa Toshinori Nakayama Kiyoshi Hirahara

Pharmacology & Therapeutics 247 108445-108445 Jul 2023 [Refereed]

CD69 imposes tumor-specific CD8+ T-cell fate in tumor-draining lymph nodes.

Ryo Koyama-Nasu Motoko Y Kimura Masahiro Kiuchi Ami Aoki Yangsong Wang Yukiyoshi Mita Ichita Hasegawa Yukihiro Endo Atsushi Onodera Kiyoshi Hirahara Shinichiro Motohashi Toshinori Nakayama

Cancer immunology research May 2023 [Refereed]

Tumor-specific CD8+ T cells play a pivotal role in anti-tumor immunity and are a key target of immunotherapeutic approaches. Intratumoral CD8+ T cells are heterogeneous; Tcf1+ stem-like CD8+ T cells give rise to their cytotoxic progeny - Tim-3+ te...

Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity.

Chiaki Iwamura Kiyoshi Hirahara Masahiro Kiuchi Sanae Ikehara Kazuhiko Azuma Tadanaga Shimada Sachiko Kuriyama Syota Ohki Emiri Yamamoto Yosuke Inaba Yuki Shiko Ami Aoki Kota Kokubo Rui Hirasawa Takahisa Hishiya Kaori Tsuji Tetsutaro Nagaoka Satoru Ishikawa Akira Kojima Haruki Mito Ryota Hase Yasunori Kasahara Naohide Kuriyama Tetsuya Tsukamoto Sukeyuki Nakamura Takashi Urushibara Satoru Kaneda Seiichiro Sakao Minoru Tobiume Yoshio Suzuki Mitsuhiro Tsujiwaki Terufumi Kubo Tadashi Hasegawa Hiroshi Nakase Osamu Nishida Kazuhisa Takahashi Komei Baba Yoko Iizumi Toshiya Okazaki Motoko Y Kimura Ichiro Yoshino Hidetoshi Igari Hiroshi Nakajima Takuji Suzuki Hideki Hanaoka Taka-Aki Nakada Yuzuru Ikehara Koutaro Yokote Toshinori Nakayama

Proceedings of the National Academy of Sciences of the United States of America 119(33) e2203437119 Aug 2022 [Refereed]

The mortality of coronavirus disease 2019 (COVID-19) is strongly correlated with pulmonary vascular pathology accompanied by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-triggered immune dysregulation and aberrant activat...

Clinical and Histological Effects of Partial Blood Flow Impairment in Vascularized Lymph Node Transfer

Shinsuke Akita Yuzuru Ikehara Minami Arai Hideki Tokumoto Yoshihisa Yamaji Kazuhiko Azuma Yoshitaka Kubota Hideaki Haneishi Motoko Y. Kimura Nobuyuki Mitsukawa

Journal of Clinical Medicine 11(14) Jul 2022 [Refereed]

Regarding vascularized lymph node transfer (VLNT) for lymphedema, partial blood flow impairment in transferred lymph node (LN) flaps may adversely affect the therapeutic results. We investigated the clinical and histological effects of partial blo...