Nucleic acids research 46(17) 9134-9147 2018年9月 [査読有り]
Here we show that laboratory of genetics and physiology 2 (LGP2) virus sensor protein regulates gene expression network of endogenous genes mediated by TAR-RNA binding protein (TRBP)-bound microRNAs (miRNAs). TRBP is an enhancer of RNA silencing, ...
JOURNAL OF BIOCHEMISTRY 159(3) 279-286 2016年3月 [査読有り]
Activation of antiviral innate immunity is triggered by cellular pattern recognition receptors. Retinoic acid inducible gene-I (RIG-I)-like receptors (RLRs) detect viral non-self RNA in cytoplasm of virus-infected cells and play a critical role in...
Seong-Wook Oh Koji Onomoto Mai Wakimoto Kazuhide Onoguchi Fumiyoshi Ishidate Takahiro Fujiwara Mitsutoshi Yoneyama Hiroki Kato Takashi Fujita
PLOS PATHOGENS 12(2) e1005444 2016年2月 [査読有り]
RIG-I triggers antiviral responses by recognizing viral RNA (vRNA) in the cytoplasm. However, the spatio-temporal dynamics of vRNA sensing and signal transduction remain elusive. We investigated the time course of events in cells infected with New...
The levels of expression of interferon-stimulated genes (ISGs) in liver are associated with response to treatment with pegylated interferon (PEG-IFN) plus ribavirin (RBV). However, associations between the responses of ISGs to IFN-based therapy an...
大学院国際学術研究院