Mitsutoshi Yoneyama Koji Onomoto Michihiko Jogi Teppei Akaboshi Takashi Fujita
CURRENT OPINION IN IMMUNOLOGY 32 48-53 2015年2月 [査読有り]
In higher vertebrates, recognition of the non-self signature of invading viruses by genome-encoded pattern recognition receptors initiates antiviral innate immunity. Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) detect viral RNA as ...
Koji Onomoto Mitsutoshi Yoneyama Gabriel Fung Hiroki Kato Takashi Fujita
TRENDS IN IMMUNOLOGY 35(9) 420-428 2014年9月 [査読有り]
Viral infection triggers the activation of antiviral innate immune responses in mammalian cells. Viral RNA in the cytoplasm activates signaling pathways that result in the production of interferons (IFNs) and IFN-stimulated genes. Some viral infec...
Ji-Seung Yoo Kiyohiro Takahasi Chen Seng Ng Ryota Ouda Koji Onomoto Mitsutoshi Yoneyama Janice Ching Lai Simon Lattmann Yoshikuni Nagamine Tadashi Matsui Kuniyoshi Iwabuchi Hiroki Kato Takashi Fujita
PLOS PATHOGENS 10(3) e1004012 2014年3月 [査読有り]
RIG-I is a DExD/H-box RNA helicase and functions as a critical cytoplasmic sensor for RNA viruses to initiate antiviral interferon (IFN) responses. Here we demonstrate that another DExD/H-box RNA helicase DHX36 is a key molecule for RIG-I signalin...
Chen Seng Ng Michihiko Jogi Ji-Seung Yoo Koji Onomoto Satoshi Koike Takuya Iwasaki Mitsutoshi Yoneyama Hiroki Kato Takashi Fujita
JOURNAL OF VIROLOGY 87(17) 9511-9522 2013年9月 [査読有り]
In response to stress, cells induce ribonucleoprotein aggregates, termed stress granules (SGs). SGs are transient loci containing translation-stalled mRNA, which is eventually degraded or recycled for translation. Infection of some viruses, includ...
Yushi Hayashi Koji Ondmoto Ryo Narita Mitsutoshi Yoneyama Hiroki Kato Takayuki Nakagawa Juichi Ito Akiko Taura Takashi Fujita
MICROBES AND INFECTION 15(8-9) 592-598 2013年7月 [査読有り]
The inner ear has been regarded as an immunoprivileged site because of isolation by the blood-labyrinthine barrier. Several reports have indicated the existence of immune cells in the inner ear, but there are no reports showing immunocompetence of...
大学院国際学術研究院