Yuya Yajima   Chu Ning Lee   Masumi Yamada   Rie Utoh   Minoru Seki   
Journal of Bioscience and Bioengineering 126(1) 111-118 2018年7月
Although the reconstruction of functional 3D liver tissue models in vitro presents numerous challenges, it is in great demand for drug development, regenerative medicine, and physiological studies. Here we propose a new approach to perform perfusi...
Cell migration and invasion are of significant importance in physiological phenomena, including wound healing and cancer metastasis. Here we propose a new system for quantitatively evaluating cancer cell invasion in a three-dimensional (3D), in vi...
Background & Aims: Since the first account of the myth of Prometheus, the amazing regenerative capacity of the liver has fascinated researchers because of its enormous medical potential. Liver regeneration is promoted by multiple types of liver ce...
Journal of Chemical Engineering of Japan 51(4) 318-330 2018年 [査読有り]
With the recent developments in microfluidic instruments and devices, various types of micrometer-sized materials have been produced by employing multiphase flow patterns formed in the microchannel. In particular, microparticles and microfibers, w...
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 177-178 2020年
A new process is presented to fabricate basement membrane-mimetic cell co-culture platforms using microfabricated PDMS stencil plates. An aqueous solution of extracellular matrices (ECM) was introduced into the through-holes of the microstencil pl...
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 1145-1146 2020年
Here we present a new approach to rapid formation of collagen gel tubes using microfluidic devices made of phosphate particle-embedding PDMS (PP-PDMS). An acidic solution of collagen, introduced into the PP-PDMS channel, was rapidly transformed in...
MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 1155-1156 2020年
Here we present an efficient microfluidic system for selectively capturing circulating tumor cells (CTCs) from blood samples, employing parallelized structures of cell trappers. The thin configuration of the trapper (depth of several micrometers) ...