Direct observation of double emulsion droplet permeation through a microchannel that mimicked 100 μm membrane pores with a porosity of 66.7% provided insights regarding splitting mechanisms in porous membranes. The microchannel was fabricated by s...
ACS Biomaterials Science and Engineering 3(9) 2144-2154 2017年9月 [査読有り]
In closely packed artificial 3D cellular constructs, cells located near the center of the constructs are not functional because of the limited supply of oxygen and nutrition. Here we describe a simple, unique, and highly versatile approach to orga...
Masumi Yamada Wataru Seko Takuma Yanai Kasumi Ninomiya Minoru Seki
Lab on a Chip 17(2) 304-314 2017年1月 [査読有り]
Hydrodynamic microfluidic platforms have been proven to be useful and versatile for precisely sorting particles/cells based on their physicochemical properties. In this study, we demonstrate that a simple lattice-shaped microfluidic pattern can wo...
Carbon nanomaterials assembled into micrometer-scale configurations are highly useful because of their unique molecular transport and adsorption properties, improved operability, and versatility in industrial/research applications. Here we propose...
Vascular tissues fabricated in vitro are useful tools for studying blood vessel-related cellular physiologies and for constructing relatively large 3D tissues. An efficient strategy for fabricating vascular tissue models with multilayered, branche...
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 177-178 2020年
A new process is presented to fabricate basement membrane-mimetic cell co-culture platforms using microfabricated PDMS stencil plates. An aqueous solution of extracellular matrices (ECM) was introduced into the through-holes of the microstencil pl...
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 1145-1146 2020年
Here we present a new approach to rapid formation of collagen gel tubes using microfluidic devices made of phosphate particle-embedding PDMS (PP-PDMS). An acidic solution of collagen, introduced into the PP-PDMS channel, was rapidly transformed in...
MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 1155-1156 2020年
Here we present an efficient microfluidic system for selectively capturing circulating tumor cells (CTCs) from blood samples, employing parallelized structures of cell trappers. The thin configuration of the trapper (depth of several micrometers) ...
大学院国際学術研究院