Dendritic cells (DC) play a key role in the initiation of both antitumor immunity and immunological tolerance. It has been demonstrated that exposure to soluble factors produced by tumor cells modulates DC functions and induces tolerogenic DC diff...
Suzuki S Sakurai D Sakurai T Yonekura S Iinuma T Okuma Y Ihara F Arai T Hanazawa T Fukuda-Kawaguchi E Ishii Y Okamoto Y
Allergology international : official journal of the Japanese Society of Allergology 68(3) 352-362 Feb 2019 [Refereed]
BACKGROUND: Sublingual immunotherapy (SLIT) is an established efficacious approach for the treatment of allergic rhinitis (AR). However, SLIT requires a long administration period to establish stable and adequate responses. This study investigated...
Ihara F Sakurai D Yonekura S Iinuma T Yagi R Sakurai T Ito T Matsuura A Morimoto Y Arai T Suzuki S Katayama K Nakayama T Okamoto Y
Allergy 73(9) 1823-1832 Sep 2018 [Refereed]
BACKGROUND: Although Th2 cells are well known to play important roles in allergic diseases including allergic rhinitis (AR), the factors that induce and sustain the pathogenesis of AR remain unclear. The recent development of sublingual immunother...
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