大学院医学研究院

研究分野

ライフサイエンス / 腫瘍生物学 / ピロリ菌胃癌
ライフサイエンス / 進化生物学 / メチローム進化

論文

SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.

Sarah Perlee Sota Kikuchi Tomoyoshi Nakadai Takeshi Masuda Sumio Ohtsuki Makoto Matsumoto Bahityar Rahmutulla Masaki Fukuyo Paolo Cifani Alex Kentsis Robert G Roeder Atsushi Kaneda Takayuki Hoshii

EMBO reports e57108 2023年8月

The H3K4 methyltransferase SETD1A plays a crucial role in leukemia cell survival through its noncatalytic FLOS domain-mediated recruitment of cyclin K and regulation of DNA damage response genes. In this study, we identify a functional nuclear loc...

Corrigendum: 'Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory genetic variations and novel oncoprotein candidates'

Vo Phuoc Tuan Koji Yahara Ho Dang Quy Dung Tran Thanh Binh Pham Huu Tung Tran Dinh Tri Ngo Phuong Minh Thuan Vu Van Khien Tran Thi Huyen Trang Bui Hoang Phuc Evariste Tshibangu-Kabamba Takashi Matsumoto Junko Akada Rumiko Suzuki Tadayoshi Okimoto Masaaki Kodama Kazunari Murakami Hirokazu Yano Masaki Fukuyo Noriko Takahashi Mototsugu Kato Shin Nishiumi Takashi Azuma Yoshitoshi Ogura Tetsuya Hayashi Atsushi Toyoda Ichizo Kobayashi Yoshio Yamaoka

Microbial genomics 9(7) 2023年7月

Association of frequent hypermethylation with high grade histological subtype in lung adenocarcinoma.

Yuki Ito Genki Usui Motoaki Seki Masaki Fukuyo Keisuke Matsusaka Takayuki Hoshii Yuki Sata Junichi Morimoto Atsushi Hata Takahiro Nakajima Bahityar Rahmutulla Taisuke Kaiho Terunaga Inage Kazuhisa Tanaka Yuichi Sakairi Hidemi Suzuki Ichiro Yoshino Atsushi Kaneda

Cancer science 114(7) 3003-3013 2023年4月

Lung adenocarcinoma is classified morphologically into five histological subtypes according to the WHO classification. While each histological subtype correlates with a distinct prognosis, the molecular basis has not been fully elucidated. Here we...

Abstract 761: Integrated environmental, lifestyle, and epigenetic risk prediction of primary gastric cancer

Genki Usui Keisuke Matsusaka Kie K. Huang Feng Zhu Tomohiro Shinozaki Masaki Fukuyo Bahityar Rahmutulla Norikazu Yogi Tomoka Okada Motoaki Seki Eiji Sakai Kazutoshi Fujibayashi Stephen K. Tsao Christopher Khor Tiing L. Ang Hiroyuki Abe Hisahiro Matsubara Masashi Fukayama Toshiaki Gunji Nobuyuki Matsuhashi Teppei Morikawa Tetsuo Ushiku Khay G. Yeoh Patrick Tan Atsushi Kaneda

Cancer Research 83(7_Supplement) 761-761 2023年4月

Abstract

Aberrant DNA methylation accumulates in non-malignant gastric mucosa after exposure to environmental pathogens such as H. pylori (HP). To understand how environmental factors and DNA methylation interplay to influence primary gastric ca...

Tumorigenic activation around HPV integrated sites in head and neck squamous cell carcinoma.

Masato Mima Atsushi Okabe Takayuki Hoshii Takuya Nakagawa Tomoya Kurokawa Satoru Kondo Harue Mizokami Masaki Fukuyo Ryoji Fujiki Bahityar Rahmutulla Tomokazu Yoshizaki Toyoyuki Hanazawa Kiyoshi Misawa Atsushi Kaneda

International journal of cancer 152(9) 1847-1862 2023年1月

Human papillomavirus (HPV) is causally involved in the development of head and neck squamous cell carcinoma (HNSCC). The integration of HPV drives tumorigenesis through expression of oncogenic viral genes as well as genomic alterations in surround...