大学院医学研究院

研究分野

ライフサイエンス / 腫瘍生物学 / ピロリ菌胃癌
ライフサイエンス / 進化生物学 / メチローム進化

論文

Characteristic DNA methylation profiles of chorionic villi in recurrent miscarriage

Yosuke Matsumoto Keiko Shinjo Shoko Mase Masaki Fukuyo Kosuke Aoki Fumiko Ozawa Hiroyuki Yoshihara Shinobu Goto Tamao Kitaori Yasuhiko Ozaki Satoru Takahashi Atsushi Kaneda Mayumi Sugiura-Ogasawara Yutaka Kondo

Scientific Reports 12(1) 11673-11673 2022年12月 [査読有り]

Abstract

Dysregulation of transcriptional programs that are tightly regulated by DNA methylation during placental and fetal development at different gestational stages, may cause recurrent miscarriage. Here, we examined genome-wide DNA methylatio...

SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia

Hoshii, T Perlee, S Kikuchi, S Rahmutulla, B Fukuyo, M Masuda, T Ohtsuki, S Soga, T Nabet, B Kaneda, A

Cell Rep. 41(9) 111727 2022年11月 [査読有り]

Histone methyltransferase SETD1A is critical for acute myeloid leukemia (AML) cell survival, but the molecular mechanism driving SETD1A gene regulation remains elusive. To delineate the role of SETD1A, we utilize a protein degrader technology to i...

Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors.

Azusa Yamato Hidekazu Nagano Yue Gao Tatsuma Matsuda Naoko Hashimoto Akitoshi Nakayama Kazuyuki Yamagata Masataka Yokoyama Yingbo Gong Xiaoyan Shi Siti Nurul Zhahara Takashi Kono Yuki Taki Naoto Furuki Motoi Nishimura Kentaro Horiguchi Yasuo Iwadate Masaki Fukuyo Bahityar Rahmutulla Atsushi Kaneda Yoshinori Hasegawa Yusuke Kawashima Osamu Ohara Tetsuo Ishikawa Eiryo Kawakami Yasuhiro Nakamura Naoko Inoshita Shozo Yamada Noriaki Fukuhara Hiroshi Nishioka Tomoaki Tanaka

Communications biology 5(1) 1304-1304 2022年11月 [査読有り]

Anti-proliferating and apoptosis-inducing activity of chemical compound FTI-6D in association with p53 in human cancer cell lines

Takato Inoue Kazuaki Matsuda Keisuke Matsusaka Masaya Nakajima Yukari Takeno Toko Miyazaki Takahiko Shintaku Natsumi Yoda Takahiko Saito Eriko Ikeda Yasunobu Mano Kenichi Shinohara Bahityar Rahmutulla Masaki Fukuyo Kazuko Kita Tetsuhiro Nemoto Atsushi Kaneda

Chemico-Biological Interactions 110257-110257 2022年11月

Repression of DERL3 via DNA methylation by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma

Satoru Kondo Atsushi Okabe Takuya Nakagawa Keisuke Matsusaka Masaki Fukuyo Bahityar Rahmutulla Hirotomo Dochi Harue Mizokami Yuki Kitagawa Tomoya Kurokawa Masato Mima Kazuhira Endo Hisashi Sugimoto Naohiro Wakisaka Kiyoshi Misawa Tomokazu Yoshizaki Atsushi Kaneda

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 166598-166598 2022年11月