American journal of physiology. Cell physiology 321(3) C596-C606 2021年9月 [査読有り]
Ceiling culture-derived preadipocytes (ccdPAs) and adipose-derived stem cells (ASCs) can be harvested from human subcutaneous fat tissue using the specific gravity method. Both cell types possess a similar spindle shape without lipid droplets. We ...
Journal of Atherosclerosis and Thrombosis 28(8) 791-801 2021年 [査読有り]
Sitosterolemia is an inherited metabolic disorder characterized by increased levels of plant sterols, such as sitosterol. This disease is caused by loss-of-function genetic mutations in ATP-binding cassette (ABC) subfamily G member 5 or member 8 (...
Journal of Atherosclerosis and Thrombosis 28(9) 883-904 2021年 [査読有り]
Primary chylomicronemia (PCM) is a rare and intractable disease characterized by marked accumulation of chylomicrons in plasma. The levels of plasma triglycerides (TGs) typically range from 1,000 - 15,000 mg/dL or higher. PCM is caused by defects ...
Journal of Atherosclerosis and Thrombosis 28(9) 905-925 2021年 [査読有り]
Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid storage disorder caused by mutations in the CYP27A1 gene, which encodes the mitochondrial enzyme sterol 27-hydroxylase. Decreased sterol 27-hydroxylase activity results in impair...
Kuroda M   Aso M   Yamamoto TT   Wada J   Ishikawa K   Maezawa Y   Teramoto N   Kubota Y   Tawada A   Aoyagi Y   Asada S   Kirinashizawa M   Onitake A   Matsuura Y   Yasunaga K   Konno S   Nishino K   Yamamoto M   Miyoshi J   Kobayashi N   Tanio M   Ikeuchi T   Igari H   Mitsukawa N   Hanaoka H   Saito Y   Yokote K   
Aso M   Yamamoto TT   Kuroda M   Wada J   Kubota Y   Ishikawa K   Maezawa Y   Teramoto N   Tawada A   Asada S   Aoyagi Y   Kirinashizawa M   Onitake A   Matsuura Y   Yasunaga K   Konno S   Nishino K   Yamamoto M   Miyoshi J   Kobayashi N   Tanio M   Ikeuchi T   Igari H   Mitsukawa N   Hanaoka H   Yokote K   Saito Y   
The American Society of Gene & Cell Therapy (ASGCT), 26th Annual Meeting 2023年5月