医学部附属病院

研究分野

ライフサイエンス / 腫瘍生物学 /

論文

臨床病理学因子と胃粘膜に蓄積したDNAメチル化を統合した一次胃癌のリスク層別化(Risk stratification of primary GC by integrating clinicopathological factors and DNA methylation in the gastric mucosa)

臼井源紀岡田朋香南瑞樹福世真樹ラヒムトラ・バハテヤリ関元昭酒井英嗣松坂恵介牛久哲男金田篤志

日本癌学会総会記事 82回 144-144 2023年9月

胃癌における遠位制御領域のDNAメチローム解析および層別化(Analysis and stratification of DNA methylome at distal regulatory regions in gastric cancer)

岡田朋香臼井源紀岡部篤史関元昭福世真樹ラヒムトラ・バハテヤリ松坂恵介牛久哲男金田篤志

日本癌学会総会記事 82回 1618-1618 2023年9月

Association of frequent hypermethylation with high grade histological subtype in lung adenocarcinoma.

Yuki Ito Genki Usui Motoaki Seki Masaki Fukuyo Keisuke Matsusaka Takayuki Hoshii Yuki Sata Junichi Morimoto Atsushi Hata Takahiro Nakajima Bahityar Rahmutulla Taisuke Kaiho Terunaga Inage Kazuhisa Tanaka Yuichi Sakairi Hidemi Suzuki Ichiro Yoshino Atsushi Kaneda

Cancer Science 114(7) 3003-3013 2023年4月 [査読有り]

Lung adenocarcinoma is classified morphologically into five histological subtypes according to the WHO classification. While each histological subtype correlates with a distinct prognosis, the molecular basis has not been fully elucidated. Here we...

Abstract 761: Integrated environmental, lifestyle, and epigenetic risk prediction of primary gastric cancer

Genki Usui Keisuke Matsusaka Kie K. Huang Feng Zhu Tomohiro Shinozaki Masaki Fukuyo Bahityar Rahmutulla Norikazu Yogi Tomoka Okada Motoaki Seki Eiji Sakai Kazutoshi Fujibayashi Stephen K. Tsao Christopher Khor Tiing L. Ang Hiroyuki Abe Hisahiro Matsubara Masashi Fukayama Toshiaki Gunji Nobuyuki Matsuhashi Teppei Morikawa Tetsuo Ushiku Khay G. Yeoh Patrick Tan Atsushi Kaneda

Cancer Research 83(7_Supplement) 761-761 2023年4月

Abstract

Aberrant DNA methylation accumulates in non-malignant gastric mucosa after exposure to environmental pathogens such as H. pylori (HP). To understand how environmental factors and DNA methylation interplay to influence primary gastric ca...

A multi-kingdom genetic barcoding system for precise target clone isolation

Soh Ishiguro Kana Ishida Rina C. Sakata Hideto Mori Mamoru Takana Samuel King Omar Bashth Minori Ichiraku Nanami Masuyama Ren Takimoto Yusuke Kijima Arman Adel Hiromi Toyoshima Motoaki Seki Ju Hee Oh Anne-Sophie Archambault Keiji Nishida Akihiko Kondo Satoru Kuhara Hiroyuki Aburatani Ramon I. Klein Geltink Yasuhiro Takashima Nika Shakiba Nozomu Yachie

bioRxiv 2023年1月

Clonal heterogeneity underlies diverse biological processes, including cancer progression, cell differentiation, and microbial evolution. Cell tagging strategies with DNA barcodes have recently enabled analysis of clone size dynamics and clone-res...