Journal of Psychopharmacology 026988112210787-026988112210787 2022年4月
Background:
Although numerous studies reported some changes of cortical silent period (CSP), an indicator of gamma-aminobutyric acid (GABA) function in central nervous system, in schizophrenia patients, it has been unknown how the disease stage ...
Nobuhisa Kanahara   Hiroshi Kimura   Yasunori Oda   Fumiaki Ito   Masaomi Iyo   
Current neuropharmacology 2022年3月
Dopamine supersensitivity psychosis is a clinical concept characterized by an unstable psychotic state and tardive dyskinesia in schizophrenia patients at the chronic stage. This state is thought to be induced by a compensatory upregulation of dop...
BACKGROUND: GABAergic system dysfunction has been implicated in the etiology of schizophrenia and of cognitive impairments in particular. Patients with treatment-resistant schizophrenia (TRS) generally suffer from profound cognitive impairments in...