RIG-I-like receptor (RLR) plays a pivotal role in the detection of invading pathogens to initiate type I interferon (IFN) gene transcription. Since aberrant IFN production is harmful, RLR signaling is strictly regulated. However, the regulatory me...
Mycobacteria possess various immunomodulatory molecules on the cell wall. Mannose-capped lipoarabinomannan (Man-LAM), amajor lipoglycan of Mycobacterium tuberculosis, has long been known to have both inhibitory and stimulatory effects on host immu...
Viral infection triggers the activation of antiviral innate immune responses in mammalian cells. Viral RNA in the cytoplasm activates signaling pathways that result in the production of interferons (IFNs) and IFN-stimulated genes. Some viral infec...
Ji-Seung Yoo   Kiyohiro Takahasi   Chen Seng Ng   Ryota Ouda   Koji Onomoto   Mitsutoshi Yoneyama   Janice Ching Lai   Simon Lattmann   Yoshikuni Nagamine   Tadashi Matsui   Kuniyoshi Iwabuchi   Hiroki Kato   Takashi Fujita   
PLOS PATHOGENS 10(3) e1004012 2014年3月 [査読有り]
RIG-I is a DExD/H-box RNA helicase and functions as a critical cytoplasmic sensor for RNA viruses to initiate antiviral interferon (IFN) responses. Here we demonstrate that another DExD/H-box RNA helicase DHX36 is a key molecule for RIG-I signalin...
Chen Seng Ng   Michihiko Jogi   Ji-Seung Yoo   Koji Onomoto   Satoshi Koike   Takuya Iwasaki   Mitsutoshi Yoneyama   Hiroki Kato   Takashi Fujita   
JOURNAL OF VIROLOGY 87(17) 9511-9522 2013年9月 [査読有り]
In response to stress, cells induce ribonucleoprotein aggregates, termed stress granules (SGs). SGs are transient loci containing translation-stalled mRNA, which is eventually degraded or recycled for translation. Infection of some viruses, includ...