Sakane Fumio

Name	Sakane Fumio
URL	http://sakane32.wix.com/biofunctionchemistry
Affiliation	Chiba University
Section	Graduate School of Science, Department of Chemistry
Job title	Professor
Degree	Ph. D.(Hokkaido University)
J-Global ID	200901073446504210

Research Interests

ジアシルグリセロールキナーゼ ,ホスファチジン酸 ,ジアシルグリセロール ,亜鉛フィンガー ,EFーハンド ,ホスファチジン酸ホスファターゼ ,プロテインキナーゼC ,アポトーシス ,cDNAクローニング ,アイソザイム ,NF-κB ,Rac1 ,糖尿病 ,カルシウム ,脂質ラフト ,リゾホスファチジン酸 ,上皮増殖因子 ,インスリン受容体 ,上皮増殖因子受容体 ,TACE ,リン酸化 ,β2-カイメリン ,プレクストリンホモロジードメイン ,肝細胞がん ,PI代謝回転 ,lipid phosphate phosphatase ,ジグリセリドキナーゼ ,質量分析法 ,細胞骨格系 ,ホスホリパーゼ ,生化学分子生物学 ,Diacylglycerol kinase

Research Areas

Life sciences / Functional biochemistry /
Life sciences / Pharmaceuticals - health and biochemistry /
Life sciences / Medical biochemistry /

Research History

Apr 2009

Today

Chiba University

Education

1987

Hokkaido University

1987

Hokkaido University Graduate School, Division of Pharmaceutical Sciences

1982

Hokkaido University Faculty of Pharmaceutical Sciences Department of Pharmacy

1982

Hokkaido University Faculty of Pharmaceutical Science

Papers

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Human sphingomyelin synthase 2 exhibit phosphatidylcholine/phosphatidylethanolamine phospholipase C activity(タイトル和訳中)

Dilimulati Kamila Murakami Chiaki Atsuta-Tsunoda Kyoko Inomata Sho Kawai Takuma Sakane Fumio

日本生化学会大会プログラム・講演要旨集 96回 [1P-075] Oct 2023

PHOSPHO1はホスファチジルコリンとホスファチジルエタノールアミンに対するホスホリパーゼC活性を持つ

村上千明堺弘道角田京子[熱田] Dilimulati Kamila 川合巧真猪俣翔坂根郁夫

日本生化学会大会プログラム・講演要旨集 96回 [1P-076] Oct 2023

Human sphingomyelin synthase 1 generates diacylglycerol in the presence and absence of ceramide via multiple enzymatic activities

Rika Suzuki Chiaki Murakami Kamila Dilimulati Kyoko Atsuta‐Tsunoda Takuma Kawai Fumio Sakane

FEBS Letters Sep 2023

Sphingomyelin (SM) synthase 1 (SMS1), which is involved in lipodystrophy, deafness, and thrombasthenia, generates diacylglycerol (DG) and SM using phosphatidylcholine (PC) and ceramide as substrates. Here, we found that SMS1 possesses DG‐generatin...

Diacylglycerol kinase ζ interacts with sphingomyelin synthase 1 and sphingomyelin synthase-related protein via different regions.

Masataka Furuta Chiaki Murakami Yuki Numagami Rika Suzuki Fumio Sakane

FEBS open bio May 2023 [Refereed]

We previously reported that diacylglycerol (DG) kinase (DGK) δ interacts with DG-generating sphingomyelin synthase (SMS)-related protein (SMSr), but not SMS1 or SMS2, via their sterile α motif domains (SAMDs). However, it remains unclear whether o...

Identification and characterization of diacylglycerol kinase ζ as a novel enzyme producing ceramide-1-phosphate

Ayako Yamazaki Ayane Kawashima Takuya Honda Takafumi Kohama Chiaki Murakami Fumio Sakane Toshihiko Murayama Hiroyuki Nakamura

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 159307-159307 Mar 2023 [Refereed]