Sakane Fumio

Name	Sakane Fumio
URL	http://sakane32.wix.com/biofunctionchemistry
Affiliation	Chiba University
Section	Graduate School of Science, Department of Chemistry
Job title	Professor
Degree	Ph. D.(Hokkaido University)
J-Global ID	200901073446504210

Research Interests

ジアシルグリセロールキナーゼ ,ホスファチジン酸 ,ジアシルグリセロール ,亜鉛フィンガー ,EFーハンド ,ホスファチジン酸ホスファターゼ ,プロテインキナーゼC ,アポトーシス ,cDNAクローニング ,アイソザイム ,NF-κB ,Rac1 ,糖尿病 ,カルシウム ,脂質ラフト ,リゾホスファチジン酸 ,上皮増殖因子 ,インスリン受容体 ,上皮増殖因子受容体 ,TACE ,リン酸化 ,β2-カイメリン ,プレクストリンホモロジードメイン ,肝細胞がん ,PI代謝回転 ,lipid phosphate phosphatase ,ジグリセリドキナーゼ ,質量分析法 ,細胞骨格系 ,ホスホリパーゼ ,生化学分子生物学 ,Diacylglycerol kinase

Research Areas

Life sciences / Functional biochemistry /
Life sciences / Pharmaceuticals - health and biochemistry /
Life sciences / Medical biochemistry /

Research History

Apr 2009

Today

Chiba University

Education

1987

Hokkaido University

1987

Hokkaido University Graduate School, Division of Pharmaceutical Sciences

1982

Hokkaido University Faculty of Pharmaceutical Sciences Department of Pharmacy

1982

Hokkaido University Faculty of Pharmaceutical Science

Papers

<2 345 6 >

The SAC1 phosphatase domain of synaptojanin‐1 is activated by interacting with polyunsaturated fatty acid‐containing phosphatidic acids

Fumi Hoshino Fumio Sakane

FEBS Letters Aug 2021 [Refereed]

Diacylglycerol kinase η colocalizes and interacts with apoptosis signal-regulating kinase 3 in response to osmotic shock

Yuji Suzuki Maho Asami Daisuke Takahashi Fumio Sakane

Biochemistry and Biophysics Reports 26 101006-101006 Jul 2021 [Refereed]

Diacylglycerol kinase (DGK) η translocates from the cytoplasm to punctate vehicles via osmotic shock. Apoptosis signal-regulating kinase (ASK) 3 (MAP kinase kinase kinase (MAPKKK) 15) is also reported to respond to osmotic shock. Therefore, in the...

Diacylglycerol Kinase η Activity in Cells Using Protein Myristoylation and Cellular Phosphatidic Acid Sensor

Ayuka Ishizaki Chiaki Murakami Haruka Yamada Fumio Sakane

Lipids 56(4) 449-458 Jul 2021 [Refereed]

Membrane morphology determines diacylglycerol kinase α substrate acyl chain specificity

José Carlos Bozelli Jenny Yune Daisuke Takahashi Fumio Sakane Richard M. Epand

The FASEB Journal 35(6) e21602 Jun 2021 [Refereed]

Diacylglycerol kinases catalyze the ATP-dependent phosphorylation of diacylglycerol (DAG) to produce phosphatidic acid (PA). In humans, the alpha isoform (DGKα) has emerged as a potential target in the treatment of cancer due to its anti-tumor and...

Combined inhibition/silencing of diacylglycerol kinase α and ζ simultaneously and synergistically enhances interleukin‐2 production in T cells and induces cell death of melanoma cells

Saki Takao Rino Akiyama Fumio Sakane

Journal of Cellular Biochemistry 122(5) 494-506 May 2021 [Refereed]