The highly enantioselective synthesis of p-anisoin was achieved via the benzoin condensation of a prochiral p-anisaldehyde using achiral NHC catalysts such as vitamin B1. In this reaction, p-anisoin crystallized as a conglomerate, and the deracemi...
We synthesized a series of phosphine-olefin-type chiral aminophosphines, and we confirmed that these each exists as two rotamers at the C(aryl)-N(amine) bond. We also investigated the ability of these aminophosphines to act as chiral ligands for P...
Yasushi Yoshida Seitaro Ishikawa Takashi Mino Masami Sakamoto
CHEMICAL COMMUNICATIONS 57(20) 2519-2522 2021年3月
Bromonium salts have been typically but infrequently used in various reactions as good leaving groups or as aryl or vinyl transfer reagents owing to their extremely high nucleofugality. Herein, we report the synthesis of novel, stable bromonium sa...
<p>α-Tetrasubstituted-α-amino thioesters were synthesised through chiral phase-transfer catalysed Michael reaction of imino thioesters in up to 97% yield with up to 81% ee.</p>
Seven racemic 5,7-dimethoxyflavanones afforded conglomerate crystals upon recrystallization from a solvent. Three methodologies were investigated to achieve asymmetric transformation based on dynamic crystallization of the chiral conglomerate syst...
大学院国際学術研究院