JOURNAL OF BIOMEDICAL OPTICS 14(5) 054017 2009年9月 [査読有り]
Animal imaging sources have become an indispensable material for biological sciences. Specifically, gene-encoded biological probes serve as stable and high-performance tools to visualize cellular fate in living animals. We use a somatic cell cloni...
Nomoto, T Okada, T Shimazaki, K Yoshioka, T Nonaka-Sarukawa, M Ito, T Takeuchi, K Katsura, K.I Mizukami, H Kume, A Ookawara, S Ikeda, U Katayama, Y Ozawa, K
YH Liu T Okada K Sheykholeslami K Shimazaki T Nomoto SI Muramatsu T Kanazawa K Takeuchi R Ajalli H Mizukami A Kume K Ichimura K Ozawa
MOLECULAR THERAPY 12(4) 725-733 2005年10月 [査読有り]
Recombinant adeno-associated virus (AAV) vectors are of interest for cochlear gene therapy because of their ability to mediate the efficient transfer and long-term stable expression of therapeutic genes in a wide variety of postmitotic tissues wit...
Background. The characteristics of adenovirus-mediated gene transfer into the kidney are not well examined. We studied the effects of contact time and temperature on adenovirus-mediated transgene expression in rat kidneys, using catheter-based in ...
Rodent and human clinical studies have shown that transplantation of bone marrow stem cells to the ischemic myocardium results in improved cardiac function. In this study, cynomolgus monkey acute myocardial infarction was generated by ligating the...
BACKGROUND: To achieve human embryonic stem (ES) cell-based transplantation therapies, allogeneic transplantation models of nonhuman primates would be useful. We have prepared cynomolgus ES cells genetically marked with the green fluorescent prote...
K Takeuchi A Sereemaspun T Inagaki Y Hakamata T Kaneko T Murakami M Takahashi E Kobayashi S Ookawara
ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY 274A(2) 883-886 2003年10月
Transgenic (Tg) animals with reporter genes are useful models in which to study cell lineage and the process of differentiation into tissues. We developed the green fluorescent protein (GFP)-Tg rat, which is more suitable for transplantation and s...
S Ueno R Ohki T Hashimoto T Takizawa K Takeuchi Y Yamashita J Ota YL Choi T Wada K Koinuma K Yamamoto U Ikeda K Shimada H Mano
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 307(4) 771-777 2003年8月
Dahl salt-sensitive rats are genetically hypersensitive to sodium intake. When fed a high sodium diet, they develop systemic hypertension, followed by cardiac hypertrophy and finally heart failure within a few months. Therefore, Dahl rats represen...
Cell transplantation and regeneration therapy are potentially new therapeutic approaches for cardiovascular disease. Transgenic (tg) animals for reporter genes would be useful to follow the cell lineage and differentiation during development and r...
M Takahashi Y Hakamata T Murakami S Takeda T Kaneko K Takeuchi R Takahashi M Ueda E Kobayashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305(4) 904-908 2003年6月
Animals transgenic (Tg) for reporter genes would be useful to following a given cell lineage during differentiation and regeneration processes. Here, we established a P-galactosidase (lacZ) Tg rat to use as a tool for regenerative research. Strong...
大学院国際学術研究院