SIRT1 is a mammalian homologue of NAD+-dependent deacetylase sirtuin family. It regulates longevity in several model organisms and is involved with cell survival, differentiation, metabolism among other processes in mammali...
The critical role of protein synthesis in regulating lifespan has been evidenced. This study shows that adult-onset RNAi inactivation of eukaryotic initiation factor 2B delta (eIF2B delta/F11A3.2), a subunit of eIF2B, extends the mean lifespan of ...
Masayoshi Suda   Katsuhiko Hata   Aika Sawada   Yuka Nakamura   Takekazu Kubo   Atsushi Yamaguchi   Toshihide Yamashita   
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 371(3) 501-504 2008年7月 [査読有り]
Repulsive guidance molecule (RGM) is a membrane-bound protein that was originally identified as an axon guidance molecule in the visual system [T. Yamashita, BK Mueller, K. Hata, Neogenin and RGM signaling in the central nervous system, Curt. Opin...