知花博治

研究者氏名	知花博治
	チバナヒロジ
URL
所属	千葉大学
部署	真菌医学研究センター
職名	准教授
学位	博士（医学）(名古屋大学), Ph. D. of Medical Science
J-Global ID	200901052291283800

研究キーワード

Genomics on drug development ,病原真菌 Pathogenic fungi 酵母 Yeast ｹﾞﾉﾑ構造 Genome structure ｹﾞﾉﾑ機能 Genome function ゲノム創薬 Drug development ,Genomics on drug development ,Pathogenic fungi Yeast Genome structure Genome function Drug development

研究分野

ライフサイエンス / 細菌学 /
ライフサイエンス / 分子生物学 /

経歴

2001年

千葉大学真菌医学研究センター

学歴

1995年

名古屋大学大学院医学系研究科博士課程

論文

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A Putative NADPH Oxidase Gene in Unicellular Pathogenic Candida glabrata Is Required for Fungal ROS Production and Oxidative Stress Response

Lin M Huang Y Orihara K Chibana H Kajiwara S Chen X

Journal of fungi (Basel, Switzerland) 2023年12月 [査読有り]

Evaluation of antifungal selective toxicity using Candida glabrata ERG25 and human SC4MOL knock-in strains

Keiko Nakano Michiyo Okamoto Azusa Takahashi-Nakaguchi Kaname Sasamoto Masashi Yamaguchi Hiroji Chibana

Journal of fungi (Basel, Switzerland) 2023年10月 [査読有り]

Retractile motion of the longitudinal flagellum in a dinoflagellate, Akashiwo sanguinea

Tadashi Maruyama Masashi Yamaguchi Akihiro Tame Takashi Toyofuku Hiroji Chibana Manabu Yoshida

CYTOLOGIA 2023年8月 [査読有り]

Activation of CWI pathway through high hydrostatic pressure, enhancing glycerol efflux via the aquaglyceroporin Fps1 in Saccharomyces cerevisiae.

Takahiro Mochizuki Toshiki Tanigawa Seiya Shindo Momoka Suematsu Yuki Oguchi Tetsuo Mioka Yusuke Kato Mina Fujiyama Eri Hatano Masashi Yamaguchi Hiroji Chibana Fumiyoshi Abe

Molecular biology of the cell mbcE23030086 2023年6月 [査読有り]

The fungal cell wall is the initial barrier for the fungi against diverse external stresses, such as osmolarity changes, harmful drugs, and mechanical injuries. This study explores the roles of osmoregulation and the cell wall integrity (CWI) path...

Evaluation of a Novel FKS1 R1354H Mutation Associated with Caspofungin Resistance in Candida auris Using the CRISPR-Cas9 System.

Maiko Kiyohara Taiga Miyazaki Michiyo Okamoto Tatsuro Hirayama Koichi Makimura Hiroji Chibana Nana Nakada Yuya Ito Makoto Sumiyoshi Nobuyuki Ashizawa Kazuaki Takeda Naoki Iwanaga Takahiro Takazono Koichi Izumikawa Katsunori Yanagihara Shigeru Kohno Hiroshi Mukae

Journal of fungi (Basel, Switzerland) 9(5) 2023年4月 [査読有り]

Outbreaks of invasive infections, with high mortality rates, caused by multidrug-resistant Candida auris have been reported worldwide. Although hotspot mutations in FKS1 are an established cause of echinocandin resistance, the actual contribution ...