Genomics on drug development
,病原真菌 Pathogenic fungi 酵母 Yeast ゲノム構造 Genome structure ゲノム機能 Genome function ゲノム創薬 Drug development
,Genomics on drug development
,Pathogenic fungi Yeast Genome structure Genome function Drug development
Pedro Pais   Raquel Califórnia   Mónica Galocha   Romeu Viana   Mihaela Ola   Mafalda Cavalheiro   Azusa Takahashi-Nakaguchi   Hiroji Chibana   Geraldine Butler   Miguel C Teixeira   
Antimicrobial agents and chemotherapy 64(9) 2020年8月 [査読有り]
The ability to acquire azole resistance is an emblematic trait of the fungal pathogen Candida glabrata Understanding the molecular basis of azole resistance in this pathogen is crucial for designing more suitable therapeutic strategies. This study...
We have been using sandwich freezing of living yeast and bacteria followed by freeze-substitution for observing close-to-native ultrastructure of cells. Recently, sandwich freezing of glutaraldehyde-fixed cultured cells and human tissues have been...
Sandwich freezing (freezing the specimen rapidly with liquid propane by placing it between two copper disks) and freeze-substitution of living yeast cells has been used for observing exquisite close-to-native ultrastructure of cells. Glutaraldehyd...