知花博治

研究者氏名	知花博治
	チバナヒロジ
URL
所属	千葉大学
部署	真菌医学研究センター
職名	准教授
学位	博士（医学）(名古屋大学), Ph. D. of Medical Science
J-Global ID	200901052291283800

研究キーワード

Genomics on drug development ,病原真菌 Pathogenic fungi 酵母 Yeast ｹﾞﾉﾑ構造 Genome structure ｹﾞﾉﾑ機能 Genome function ゲノム創薬 Drug development ,Genomics on drug development ,Pathogenic fungi Yeast Genome structure Genome function Drug development

研究分野

ライフサイエンス / 細菌学 /
ライフサイエンス / 分子生物学 /

経歴

2001年

千葉大学真菌医学研究センター

学歴

1995年

名古屋大学大学院医学系研究科博士課程

論文

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Deletion of CDR1 reveals redox regulation of pleiotropic drug resistance in Candida glabrata

Kseniia V. Galkina Michiyo Okamoto Hiroji Chibana Dmitry A. Knorre Susumu Kajiwara

Biochimie 170 49-56 2020年3月 [査読有り]

© 2019 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM) Microbial cells sense the presence of xenobiotics and, in response, upregulate genes involved in pleiotropic drug resistance (PDR). In yeast, PDR activation to...

Screening the Drug:H⁺ Antiporter Family for a Role in Biofilm Formation in Candida glabrata

Rui Santos Mafalda Cavalheiro Catarina Costa Azusa Takahashi-Nakaguchi Michiyo Okamoto Hiroji Chibana Miguel C. Teixeira

Frontiers in Cellular and Infection Microbiology 10 29-29 2020年2月 [査読有り]

© Copyright © 2020 Santos, Cavalheiro, Costa, Takahashi-Nakaguchi, Okamoto, Chibana and Teixeira. Biofilm formation and drug resistance are two key pathogenesis traits exhibited by Candida glabrata as a human pathogen. Interestingly, specific path...

Analysis of an Intrinsic Mycovirus Associated With Reduced Virulence of the Human Pathogenic Fungus Aspergillus fumigatus

Azusa Takahashi-Nakaguchi Erika Shishido Misa Yahara Syun Ichi Urayama Kanae Sakai Hiroji Chibana Katsuhiko Kamei Hiromitsu Moriyama Tohru Gonoi

Frontiers in Microbiology 10 3045-3045 2020年1月 [査読有り]

© Copyright © 2020 Takahashi-Nakaguchi, Shishido, Yahara, Urayama, Sakai, Chibana, Kamei, Moriyama and Gonoi. Aspergillus fumigatus is an airborne fungal pathogen that causes severe infections with invasive growth in immunocompromised patients. Se...

Role of major facilitator superfamily transporter Qdr2p in biofilm formation by Candida glabrata

Tria Widiasih Widiyanto Xinyue Chen Shun Iwatani Hiroji Chibana Susumu Kajiwara

Mycoses 62(12) 1154-1163 2019年12月 [査読有り]

© 2019 Blackwell Verlag GmbH Candida glabrata represents the second-most frequent cause of candidiasis infections of the mucosa, bloodstream and genito-urinary tract in immunocompromised individuals. The incidence of C glabrata infection has incre...

Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner

Reika Shiratori Kenta Furuichi Masashi Yamaguchi Natsumi Miyazaki Haruna Aoki Hiroji Chibana Kousei Ito Shigeki Aoki

Scientific Reports 9(1) 18699-18699 2019年12月 [査読有り]

© 2019, The Author(s). Most cancer cells rely on glycolysis to generate ATP, even when oxygen is available. However, merely inhibiting the glycolysis is insufficient for the eradication of cancer cells. One main reason for this is that cancer cell...