Epithelial-mesenchymal transition (EMT), a qualitative change in cell migration behavior during cancer invasion and metastasis, is becoming a new target for anticancer drugs. Therefore, it is crucial to develop in vitro assays for the evaluation o...
Norikazu Sato   Jiafeng Yao   Michiko Sugawara   Masahiro Takei   
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 66(2) 453-463 2019年2月
A particle-fluid flow under alternating current (ac) electrokinetics was numerically simulated to investigate the three-dimensional (3-D) particle motion in a complex electric field of a high conductivity medium generated by an electrode-multilaye...
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS 11(6) 1450-1458 2017年12月
The distinct motion of GFP-tagged histone expressing cells (Histone-GFP type cells) has been investigated under ac electrokinetics in an electrode-multilayered microfluidic device as compared with Wild type cells and GFP type cells in terms of dif...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114(44) E9280-E9289 2017年10月
Persistent directional cell migration is involved in animal development and diseases. The small GTPase Rac1 is involved in F-actin and focal adhesion dynamics. Local Rac1 activity is required for persistent directional migration, whereas global, h...
A method was developed for photocontrolling cell adhesion on a gel substrate with defined mechanical properties. Precise patterning of geometrically controlled cell clusters and their migration induction became possible by spatiotemporally control...
電気学会論文誌. C, 電子・情報・システム部門誌 = The transactions of the Institute of Electrical Engineers of Japan. C, A publication of Electronics, Information and System Society 131(4) 833-839 2011年
It is well known that cell migrations play a key role in the living systems. From the basic technical point of view, cell migration control is one of the important and useful ways to clarify the mechanism of the cell migration qualitatively and qu...
M Sugawara   Y Ishida   H Wada   
HEARING RESEARCH 192(1-2) 57-64 2004年6月
Mammalian hearing is refined by amplification of the motion of the cochlear partition. To understand the cochlear amplification, mechanical models of the cochlea have been used. When the dynamic behavior of the cochlea is analyzed by a model, elas...
<p>For cell discrimination of cancerous cell, diffusibility α is proposed based on the Nernst-Planck equation by Electrochemical Impedance Spectroscopy. Diffusibility α is calculated by the Nernst-Planck equation, and it means ion tr...