Epithelial-mesenchymal transition (EMT), a qualitative change in cell migration behavior during cancer invasion and metastasis, is becoming a new target for anticancer drugs. Therefore, it is crucial to develop in vitro assays for the evaluation o...
Norikazu Sato   Jiafeng Yao   Michiko Sugawara   Masahiro Takei   
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 66(2) 453-463 2019年2月
A particle-fluid flow under alternating current (ac) electrokinetics was numerically simulated to investigate the three-dimensional (3-D) particle motion in a complex electric field of a high conductivity medium generated by an electrode-multilaye...
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS 11(6) 1450-1458 2017年12月
The distinct motion of GFP-tagged histone expressing cells (Histone-GFP type cells) has been investigated under ac electrokinetics in an electrode-multilayered microfluidic device as compared with Wild type cells and GFP type cells in terms of dif...
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114(44) E9280-E9289 2017年10月
Persistent directional cell migration is involved in animal development and diseases. The small GTPase Rac1 is involved in F-actin and focal adhesion dynamics. Local Rac1 activity is required for persistent directional migration, whereas global, h...
A method was developed for photocontrolling cell adhesion on a gel substrate with defined mechanical properties. Precise patterning of geometrically controlled cell clusters and their migration induction became possible by spatiotemporally control...
As electromotility may arise from a conformational change of the molecules' 'protein motors', which might be distributed along the outer hair cell (OHC) lateral wall, the force generated by the OHC electromotility would be related not only to the ...
As electromotility may arise from a conformational change of the molecules' 'protein motors', which might be distributed along the outer hair cell (OHC) lateral wall, the force generated by the OHC electromotility would be related not only to the ...
H Wada   D Miyamoto   M Sugawara   
JSME INTERNATIONAL JOURNAL SERIES C-MECHANICAL SYSTEMS MACHINE ELEMENTS AND MANUFACTURING 45(4) 862-869 2002年12月
Although the force production of the outer hair cell (OHC) leads to the fine tuning of the mammalian cochlea, the value of the force generated by the motility of the OHC in vivo has not been clarified yet. In this study, first, the active force ge...
In this study, mechanical properties of guinea pig outer hair cells (OHCs) were measured by atomic force microscopy (AFM). First, in order to confirm the availability of AFM for measurement of the mechanical properties of the OHC, Young's moduli o...
<p>For cell discrimination of cancerous cell, diffusibility α is proposed based on the Nernst-Planck equation by Electrochemical Impedance Spectroscopy. Diffusibility α is calculated by the Nernst-Planck equation, and it means ion tr...