研究者氏名	坂本明美
	サカモトアケミ
URL
所属	千葉大学
部署	バイオメディカル研究センター
職名	准教授
学位	医学博士(千葉大学)
J-Global ID	200901012435430941

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Impaired lymphocyte development and function in Clast5/Stra13/DEC1-transgenic mice

M Seimiya A Wada K Kawamura A Sakamoto Y Ohkubo S Okada M Hatano T Tokuhisa T Watanabe H Saisho M Tagawa J O-Wang

EUROPEAN JOURNAL OF IMMUNOLOGY 34(5) 1322-1332 2004年5月

Clast5/Stra13/DEC1 is a member of the helix-loop-helix family of transcriptional repressors. We have previously shown that Clast5 is rapidly down-regulated upon B cell activation and its overexpression inhibits cell cycle progression in B lymphoma...

Impaired lymphocyte development and function in Clast5/Stra13/DEC1-transgenic mice

M Seimiya A Wada K Kawamura A Sakamoto Y Ohkubo S Okada M Hatano T Tokuhisa T Watanabe H Saisho M Tagawa J O-Wang

EUROPEAN JOURNAL OF IMMUNOLOGY 34(5) 1322-1332 2004年5月

Bcl6 acts as an amplifier for the generation and proliferative capacity of central Memory CD8⁺ T Cells

J.Immunol 173 883-891 2004年

Bcl6 is a transcriptional repressor for the IL-18 gene

N Takeda M Arima N Tsuruoka S Okada M Hatano A Sakamoto Y Kohno T Tokuhisa

JOURNAL OF IMMUNOLOGY 171(1) 426-431 2003年7月

Bc16 functions as a sequence-specific transcriptional repressor, and Bc16-deficient (Bc16(-/-)) mice have been reported to display Th2-type inflammatory diseases in multiple organs. Since IL-18 is a potent stimulator of Th2 cells, we examined the ...

CD25+CD4+T cells contribute to the control of memory CD8+T cells

M Murakami A Sakamoto J Bender J Kappler P Marrack

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(13) 8832-8837 2002年6月

Previously we demonstrated that IL-15 and IL-2 control the number of memory CD8+ T cells in mice. IL-15 induces, and IL-2 suppresses the division of these cells. Here we show that CD25+CD4+ regulatory T cells play an important role in the IL-2-med...

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