<title>Abstract</title>Although computational simulation-based natural product syntheses are in their initial stages of development, this concept can potentially become an indispensable resource in the field of organic synthesis. Herein we report ...
Chemical and Pharmaceutical Bulletin 70(3) 235-239 2022年3月 [査読有り]
Heavy atom-containing molecules cause a photoreaction by a direct S0→Tn transition. Therefore, even in a hypervalent iodine compound with a benzene ring as the main skeleton, the photoreaction proceeds under 365–400nm wavelength light, where UV-vi...
Reaction of 3-formylindole, aniline, and TMSCN under conditions of the Strecker reaction yielded a Friedel-Crafts reaction product rather than the usual aminonitrile. This abnormal Strecker reaction can be applied to various aniline and 3-formylin...
Machine learning to create models on the basis of big data enables predictions from new input data. Many tasks formerly performed by humans can now be achieved by machine learning algorithms in various fields, including scientific areas. Hypervale...
Chemical and Pharmaceutical Bulletin 71(8) 624-632 2023年8月
To develop dearomatization reactions based on a nucleophilic activation of phenols, naphthols, and indoles, ipso-Friedel–Crafts-type C-alkylation must be selectively promoted over competitive O- or N-alkylation reactions. Resolving this chemoselec...
This paper presents the advances in the synthesis of dragmacidin E. Since its isolation from a southern Australian deep-water marine sponge by Capon et al. in 1998, the Funk, Feldman, Jia, and Nemoto groups have conducted synthetic studies on this...