The total synthesis of dragmacidins G and H was achieved for the first time by employing nucleophilic aromatic substitution and site-selective cross-coupling reactions using appropriately functionalized pyrazines as substrates. The evaluation of a...
Herein, we report the unusual skeletal rearrangement of spiro[4.5]decadienone to benzoxepane. In particular, Lewis acid-promoted epoxide-opening ipso-cyclization of aryl epoxides afforded spiro[4.5]decadienone intermediates. Subsequent thermal act...
Chemical and Pharmaceutical Bulletin 71(8) 624-632 2023年8月
To develop dearomatization reactions based on a nucleophilic activation of phenols, naphthols, and indoles, ipso-Friedel–Crafts-type C-alkylation must be selectively promoted over competitive O- or N-alkylation reactions. Resolving this chemoselec...
This paper presents the advances in the synthesis of dragmacidin E. Since its isolation from a southern Australian deep-water marine sponge by Capon et al. in 1998, the Funk, Feldman, Jia, and Nemoto groups have conducted synthetic studies on this...
大学院国際学術研究院