Obesity is a major risk factor for some metabolic disorders including type 2 diabetes. Enhancement of peroxisome proliferator-activated receptor (PPAR) γ, a master regulator of adipocyte differentiation, is known to increase insulin-sensitive smal...
Daiki Nakahara   Cui Nan   Koichiro Mori   Motoki Hanayama   Haruhisa Kikuchi   Shizuka Hirai   Yukari Egashira   
European journal of nutrition 59(7) 3231-3244 2020年10月
PURPOSE: Mushrooms are reported to have a variety of health-promoting activities. However, little information is available on the effects of intake of polysaccharides from Pleurotus eryngii on obesity. In this study, we investigated the effects of...
Phytotherapy research : PTR 34(6) 1358-1366 2020年6月
Osteoporosis is associated with increase in fat tissue in bone marrow in humans. Mesenchymal stem cells in bone marrow are induced to differentiate into osteoblasts rather than adipocytes by the stimulation of peroxisome proliferator-activated rec...
Journal of nutritional science and vitaminology 65(2) 196-201 2019年
We investigated the combined effects of 'Benifuuki,' a tea cultivar that contains O-methylated catechins like epigallocatechin-3-O-(3-O-methyl) gallate, and quercetin on hepatic fat accumulation in male Sprague-Dawley rats fed a high-fat, high-cho...
ACMSD is a tryptophan metabolic key enzyme. HNF4α regulates the transcription of some energy-metabolic enzymes by cooperating with PGC1α, a major transcriptional co-regulator involved in energy metabolism. In this study, we investigated the involv...