Bioscience, biotechnology, and biochemistry 81(5) 966-971 2017年5月
Ferulic acid (FA) is a phenol compound found in plants that has anti-inflammatory properties. Indoleamine 2, 3-dioxygenase (IDO) is a tryptophan catabolic enzyme induced in immune cells, including glial cells, during inflammation. Enhanced IDO exp...
Bioscience, biotechnology, and biochemistry 79(1) 82-7 2015年
Obese adipose tissue is characterized by enhanced macrophage infiltration. A loop involving monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNFα) between adipocytes and macrophages establishes a vicious cycle that augments ...
Shizuka Hirai Sho Horii Yoshiaki Matsuzaki Shin Ono Yuki Shimmura Kenji Sato Yukari Egashira
Life sciences 117(1) 1-6 2014年11月
AIMS: Food-derived peptides have been reported to yield a variety of health promoting activities. Pyroglutamyl peptides are contained in the wheat gluten hydrolysate. In the present study, we investigated the effect of pyroglutamyl dipeptides on t...
Shizuka Hirai Chie Ohyane Young-Il Kim Shan Lin Tsuyoshi Goto Nobuyuki Takahashi Chu-Sook Kim Jihey Kang Rina Yu Teruo Kawada
American journal of physiology. Endocrinology and metabolism 306(3) E247-55 2014年2月
Recently, fibrosis is observed in obese adipose tissue; however, the pathogenesis remains to be clarified. Obese adipose tissue is characterized by chronic inflammation with massive accumulation of immune cells including mast cells. The objective ...
PURPOSE: Nicotinic acid is one of the older drugs used to treat hyperlipidemia, the greatest risk factor of coronary heart disease. Nicotinic acid is also a precursor of the coenzyme nicotinamide adenine dinucleotide (NAD). In mammals, α-amino-β-c...
大学院国際学術研究院