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大学院薬学研究院

Researcher List >> Akihiro Hisaka
 

Akihiro Hisaka

 
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NameAkihiro Hisaka
URLhttps://www.p.chiba-u.jp/lab/cpp/index.html
AffiliationChiba University
SectionGraduate School of Pharmaceutical Sciences
Job title教授
J-Global ID200901048175626060

Research Interests

 
臨床薬理学 ,薬物動態学 ,Pharmacokinetics and Clinical Pharmacology

Research Areas

 
  • Life sciences / Clinical pharmacy / 

Education

 
 
   
 
Hokkaido University Faculty of Pharmaceutical Sciences Department of Pharmacy
 
 
   
 
Hokkaido University  
 

Committee Memberships

 
 
   
 
HAB研究機構  理事
 
 
   
 
日本薬物動態学会  評議員
 

Papers

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Involvement of multiple cytochrome P450 isoenzymes in drug interactions between ritonavir and direct oral anticoagulants
Yuta Tamemoto   Yukihiro Shibata   Natsumi Hashimoto   Hiromi Sato   Akihiro Hisaka   
Drug Metabolism and Pharmacokinetics   53 100498-100498   Dec 2023
 
Model-based meta-analysis of ethnic differences and their variabilities in clearance of oral drugs classified by clearance mechanism.
Hiromi Sato   Rika Marutani   Ryota Takaoka   Daniel Mori-Fegan   Xinying Wang   Kazuya Maeda   Hiroyuki Kusuhara   Hiroshi Suzuki   Hideki Yoshioka   Akihiro Hisaka   
CPT: pharmacometrics & systems pharmacology   12(8) 1132-1142   Jun 2023
In this study, the ethnic ratios (ERs) of oral clearance between Japanese and Western populations were subjected to model-based meta-analysis (MBMA) for 81 drugs evaluated in 673 clinical studies. The drugs were classified into eight groups accord...
 
Integrated Use of In Vitro and In Vivo Information for Comprehensive Prediction of Drug Interactions Due to Inhibition of Multiple CYP Isoenzymes
Shizuka Hozuki   Hideki Yoshioka   Satoshi Asano   Mikiko Nakamura   Saori Koh   Yukihiro Shibata   Yuta Tamemoto   Hiromi Sato   Akihiro Hisaka   
Clinical Pharmacokinetics   62(6) 849-860   Apr 2023
 
Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor
Takahiro Arai   Tomomi Kokubo   Ruiheng Tang   Hirohito Abo   Ayu Terui   Jotaro Hirakawa   Hidetaka Akita   Hiroto Kawashima   Akihiro Hisaka   Hiroto Hatakeyama   
Journal for ImmunoTherapy of Cancer   10(12) e005657-e005657   Dec 2022
Background

With the increased use of immune checkpoint inhibitors (ICIs), side effects and toxicity are a great concern. Anaphylaxis has been identified as a potential adverse event induced by ICIs. Anaphylaxis is a life-threatening medical emerg...
 
Delivery of aPD-L1 antibody to i.p. tumors via direct penetration by i.p. route: Beyond EPR effect
Mayu Yamamoto   Taiki Kurino   Reiko Matsuda   Haleigh Sakura Jones   Yoshito Nakamura   Taisei Kanamori   Atushi B. Tsuji   Aya Sugyo   Ryota Tsuda   Yui Matsumoto   Yu Sakurai   Hiroyuki Suzuki   Makoto Sano   Kensuke Osada   Tomoya Uehara   Yukimoto Ishii   Hidetaka Akita   Yasushi Arano   Akihiro Hisaka   Hiroto Hatakeyama   
Journal of Controlled Release   352 328-337   Dec 2022   [Refereed]

Misc.

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熱ストレス下における熱耐性卵巣癌細胞の代謝シフトの解明
金森大誠   宮崎菜摘   青木重樹   伊藤晃成   樋坂章博   畠山浩人   
日本薬学会関東支部大会講演要旨集   65th (CD-ROM)    2021
 
薬物動態に影響する高齢者の生理学的変化と性差
佐藤洋美   副島呉竹   副島呉竹   樋坂章博   
日本性差医学・医療学会学術集会プログラム・抄録集   14th    2021
 
Importance of systematic assessment of time-dependent inhibition of CYP isozymes: inhibition of CYP1A2 and CYP2C19 by fluvoxamine
爲本雄太   柴田侑裕   吉友葵   佐藤洋美   樋坂章博   
日本薬剤学会年会講演要旨集(CD-ROM)   36th    2021
 
Proposal of a New Risk Score for Hospital Death Due to Acute Coronary Syndrome Developed by Machine Learning
Hideki Yoshioka   Akihiro Hisaka   Yasunori Sato   
CIRCULATION RESEARCH   127(12) E281-E281   Dec 2020
 
代謝寄与率(fm)の評価に与える緩衝液条件の影響:in vitroカクテル法による検討
爲本雄太   柴田侑裕   保月静香   佐藤洋美   樋坂章博   
臨床薬理   51(Supplement)    2020

Books and Other Publications

 
 
大野, 能之, 樋坂, 章博
南山堂   Aug 2019   (ISBN:9784525776015)
 
大野, 能之, 樋坂, 章博, 鈴木, 洋史
じほう   Feb 2014   (ISBN:9784840745604)
 
樋坂, 章博
樋坂章博   Mar 2010   

Professional Memberships

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国際薬物動態学会
 
   
 
日本ファーマコメトリクス研究会
 
   
 
日本TDM学会
 
   
 
日本臨床薬理学会
 
   
 
日本医療薬学会

Research Projects

123>
 
 
Significance of ketone body metabolic shift in diabetes and long-term prognosis prediction
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2021 - Mar 2024
 
Model based meta-analysis and establishment of PBPK model for appropriate use of factor Xa inhibitor
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Sato Hiromi 
Project Year: Apr 2017 - Mar 2020
 
Expression of precipitating factors of pruritus found in humans in an imiquimodinduced psoriasis mouse model
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Yamaura Katsunori OISHI nobuo 
Project Year: Apr 2015 - Mar 2019
 
Epigenetic regulation shifted cellular metabolism of cancer cells, which contributed to potentiate drug sensitivity of antiangiogenic agents.
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Sato Hiromi HISAKA Akihiro 
Project Year: Apr 2015 - Mar 2017
 
Development of Micro-blood-sampling Method for Pharmacokinetic Analysis in Clinical Studies
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
HISAKA Akihiro 
Project Year: Apr 2013 - Mar 2015
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