CPT: pharmacometrics & systems pharmacology 2021年7月
To characterize and compare various medicines for chronic heart failure (CHF), changes in circulatory physiological parameter during pharmacotherapy were investigated by a model-based meta-analysis (MBMA) of circulatory physiology. The clinical da...
Drug metabolism and disposition: the biological fate of chemicals 2021年5月
Precise prediction of drug absorption is key to the success of new drug development and efficacious pharmacotherapy. In this study, we developed a new absorption model, the advanced translocation model (ATOM), by extending our previous model, the ...
Riki Cho   Yu Sakurai   Haleigh Sakura Jones   Hidetaka Akita   Akihiro Hisaka   Hiroto Hatakeyama   
Cancers 12(12) 2020年12月
Despite the promising anticancer effects of immune checkpoint inhibitors, their low objective response rate remains to be resolved; thus, combination therapies have been investigated. We investigated the combination of an anti-programmed cell deat...
Chemical & pharmaceutical bulletin 68(9) 891-894 2020年9月
In pharmacokinetic (PK) analysis, conventional models are described by ordinary differential equations (ODE) that are generally solved in their Laplace transformed forms. The solution in the Laplace transformed forms is inverse Laplace transformed...