Masanobu Sato   Kota Toshimoto   Atsuko Tomaru   Takashi Yoshikado   Yuta Tanaka   Akihiro Hisaka   Wooin Lee   Yuichi Sugiyama   
Drug metabolism and disposition: the biological fate of chemicals 46(5) 740-748 2018年5月
Bosentan is a substrate of hepatic uptake transporter organic anion-transporting polypeptides (OATPs), and undergoes extensive hepatic metabolism by cytochrome P450 (P450), namely, CYP3A4 and CYP2C9. Several clinical investigations have reported a...
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 34(3) 280-286 2018年4月
PURPOSE: To investigate the effect of excipients on latanoprost penetration into the aqueous humor with clinically available 6 products with different solutions mainly in the types and concentrations of preservatives. METHODS: In 363 patients with...
Acquired resistance to sunitinib is a challenge in the treatment of renal cell carcinoma (RCC). The dysregulation of cellular metabolism is prevalent during resistance acquisition. It is known that in sunitinib-resistant RCC 786-O (786-O Res) cell...
Journal of clinical pharmacology 57(11) 1491-1499 2017年11月
In this study, impact of a polymorphism of CYP2C19 on drug-drug interaction (DDI) was examined for etizolam. The effect of itraconazole (a strong CYP3A inhibitor) on the pharmacokinetics of etizolam (a substrate of CYP2C19 and CYP3A) was assessed ...
Journal of pharmaceutical sciences 106(9) 2771-2779 2017年9月
In this study, intestinal drug-drug interactions (DDIs) for substrate drugs of P-glycoprotein were simulated extensively using the extended QGut model and translocation model to explore the determinants of DDI. The results of analyses using both m...