Journal of pharmacological sciences 134(2) 101-107 2017年6月
The constituent protein of gap junctions, connexin (Cx), interacts with various proteins via its C-terminus region, including kinases, cell-adhesion proteins, and a pro-apoptotic protein, Bax. This molecular interaction may affect expression and f...
Aprepitant is a known inducer of CYP2C9, the main warfarin-metabolizing enzyme. Consequently, co-administration of these two drugs may result in reduction of the anticoagulation activity of warfarin. However, the nature and degree of time-dependen...
Naoki Ito   Kousei Ito   Yuki Ikebuchi   Yu Toyoda   Tappei Takada   Akihiro Hisaka   Akira Oka   Hiroshi Suzuki   
Pharmaceutical research 32(8) 2527-37 2015年8月 [査読有り]
PURPOSE: Drug transfer into milk is of concern due to the unnecessary exposure of infants to drugs. Proposed prediction methods for such transfer assume only passive drug diffusion across the mammary epithelium. This study reorganized data from th...
Drug metabolism and disposition: the biological fate of chemicals 43(4) 590-602 2015年4月
This study aimed to construct a new local pharmacokinetic model of gastrointestinal absorption, the translocation model (TLM), using an anatomically relevant, minimally segmented structure to explain linear and nonlinear intestinal absorption, met...