Masaru Kondo   Naoki Matsuyama   Tin Z. Aye   Irshad Mattan   Tomoyuki Sato   Yoshinori Makita   Masami Ishibashi   Midori A. Arai   Shinobu Takizawa   Hiroaki Sasai   
Advanced Synthesis and Catalysis 363(10) 2648-2663 2021年5月 [査読有り]
A stereoselective synthetic route to chiral C3-spirooxindole- and C2-spiropseudoindoxyl-pyrrolidines was accomplished by an enantioselective organocatalyzed Pictet-Spengler reaction of tryptamines and isotryptamines followed by a diastereoselectiv...
Journal of Antibiotics 74(4) 255-259 2021年4月 [査読有り]
Notch signaling inhibitors with the potential of immune suppressor production by pathogenic bacteria for easy host infection were searched from extracts of Nocardia sp. Nocobactin NA-a (compound 1) and nocobactin NA-b (compound 2), which have been...
Planta Medica International Open 8(01) e19-e24 2021年3月 [査読有り]
<title>Abstract</title>Alzheimer’s disease is a typical neurodegenerative disorder, and its prevention or treatment poses great concern in advanced countries. In our survey of numerous natural resources with neurotrophic activities, we found that ...
To identify bioactive natural products from various natural resources, such as plants and microorganisms, we investigated programs to screen for compounds that affect several cancer-related cellular signaling pathways, such as BMI1, TRAIL, and Wnt...
Pulmonary arterial hypertension (PAH) is a rare and severe progressive disorder characterized by high pulmonary artery pressure. Chronic hypoxia causes a metabolic disorder and the Warburg effect in pulmonary arterial smooth muscle cells (PASMCs)....