Yasumasa Hara   Yuichi Totsugi   Hiroshi Ichikawa   Shinji Harada   Kazuki Fujii   Firoj Ahmed   Samir K. Sadhu   Midori A. Arai   Masami Ishibashi   
Journal of Natural Medicines 75(1) 99-104 2021年1月 [査読有り]
A novel C20 natural product, acacienone (1), was isolated from the leaves of Acacia mangium collected in Bangladesh. The structure of compound 1 was elucidated by spectral studies and X-ray crystallographic analysis. Acacienone (1) possesses a ter...
Lindbladione (1) is a neural stem cell differentiation activator isolated from Lindbladia tubulina by our group. Hes1 dimerization inhibitory activity of lindbladione (1) was discovered using our original fluorescent Hes1 dimer microplate assay. W...
Midori A. Arai   Kaori Morita   Haruka Kawano   Yuna Makita   Manami Hashimoto   Akiko Suganami   Yutaka Tamura   Samir K. Sadhu   Firoj Ahmed   Masami Ishibashi   
Scientific Reports 10(1) 2020年12月 [査読有り]
Natural products isolation using protein based methods is an attractive for obtaining bioactive compounds. To discover neural stem cell (NSC) differentiation activators, we isolated eight inhibitors of Hes1 dimer formation from Psidium guajava usi...
Anna Tsuchiya   Yoshinori Makita   Takashi Koyano   Thaworn Kowithayakorn   Masami Ishibashi   Midori A. Arai   
Journal of Natural Medicines 74(4) 758-766 2020年9月 [査読有り]
Abstract: Since Notch signaling plays important roles in cell proliferation and differentiation, aberrant activation of this signaling contributes to cancer progression. In neural stem cells, Notch signaling inhibits differentiation by activating ...
International Journal of Peptide Research and Therapeutics 26(1) 281-290 2020年3月 [査読有り]
Nocardithiocin is a thiopeptide compound produced by the pathogenic actinomycete Nocardia pseudobrasiliensis that displays activity against Gram-positive bacteria including drug-resistant Mycobacterium tuberculosis. However, the clinical use of no...