Tomoyuki Sato   Midori A. Arai   Yixizhuoma   Yasumasa Hara   Takashi Koyano   Thaworn Kowithayakorn   Masami Ishibashi   
Journal of Natural Medicines 74(2) 476-481 2020年3月 [査読有り]
Upon screening compounds having Wnt signal inhibitory activity through evaluating TCF/β-catenin transcriptional (TOP) activity, eight cadinane sesquiterpenoids, including three new compounds (1–3), were isolated from wood extracts of Santalum albu...
Because research on the genus Nocardia has not progressed as compared to the extensively studied genus Streptomyces, Nocardia is considered as a useful undeveloped resource for exploring natural products. In this study, a new γ-butyrolactone deriv...
Endo, Y.   Kasahara, T.   Asakura, K.   Mori, A.   Funasaki, M.   Akisue, G.   Etoh, T.   Harada, K.   Fukuyama, Y.   Matsuzaki, K.   Ishibashi, M.   Ohsaki, A.   
Yokoyama, Y.   Arai, M.A.   Hara, Y.   Ishibashi, M.   
Bioorganic and Medicinal Chemistry 27(13) 2998-3003 2019年 [査読有り]
B-cell-specific Moloney murine leukemia virus region 1 (BMI1) is a central component of polycomb repressive complex 1 (PRC1), which maintains epigenetic repression of genes expression via chromatin condensation. BMI1 overexpression downregulates t...