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大学院医学研究院

Researcher List >> Hiroshi Shirasawa
 

Hiroshi Shirasawa

 
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NameHiroshi Shirasawa
URL
AffiliationChiba University
SectionSchool of Medicine
Job titleProfessor
Degree(BLANK)(Chiba University)
J-Global ID200901055639615933

Research Interests

 
ウイルス 分子生物学 Molecular Biology Cancer Studies ,Molecular Biology Cancer Studies

Research Areas

 
  • Life sciences / Virology / 

Papers

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PKR-NF-κB Pathway Upstream of IFN-β Induction Is Dysregulated in Oncolytic Sindbis Virus-infected HeLa Cells
XUE MA   TOMOKO OGAWA   ZHENG TIAN   RUIRONG YI   KANG TANG   KENGO SAITO   SARA YATABE   YOSHIFUMI OHNO   RYOSUKE MUROYAMA   EIJI IDO   HISAHIRO MATSUBARA   HIROSHI SHIRASAWA   
Anticancer Research   43(7) 2923-2932   Jun 2023
 
CCL299, a Benzimidazole Derivative Induces G1 Phase Arrest and Apoptosis in Cancer Cells
YOSHIFUMI OHNO   RUIRONG YI   AKIKO SUGANAMI   YUTAKA TAMURA   AKIO MATSUMOTO   SHOJI MATSUMOTO   KENGO SAITO   HIROSHI SHIRASAWA   
Anticancer Research   41(2) 699-706   Feb 2021
 
CCL113, a novel sulfonamide, induces selective mitotic arrest and apoptosis in HeLa and HepG2 cells
Ruirong Yi   Yoshifumi Ohno   Zheng Tian   Shuhan Guo   Weiwei Chen   Xue Ma   Nan Win   Qisen Li   Majid Vahed   Kengo Saito   Shingo Nakamoto   Akiko Suganami   Naohisa Isegawa   Keisuke Yoshida   Shinji Harada   Yutaka Tamura   Atsushi Nishida   Hiroshi Shirasawa   
Oncology Reports   44(6) 2770-2782   Oct 2020
 
Sindbis viral structural protein cytotoxicity on human neuroblastoma cells
Eriko Y. Saito   Kengo Saito   Tomoro Hishiki   Ayako Takenouchi   Takeshi Saito   Yoshiharu Sato   Keita Terui   Tadashi Matsunaga   Hiroshi Shirasawa   Hideo Yoshida   
Pediatric Surgery International   36(10) 1173-1180   Oct 2020
Purpose: Oncolytic viral therapy for neuroblastoma (NB) cells with Sindbis virus (SINV) is a promising strategy for treating high-risk NB. Here, we evaluated the possibility of using SINV structural proteins as therapeutic agents for NB since UV-i...
 
Sindbis viral structural protein cytotoxicity on human neuroblastoma cells.
Eriko Y Saito   Kengo Saito   Tomoro Hishiki   Ayako Takenouchi   Takeshi Saito   Yoshiharu Sato   Keita Terui   Tadashi Matsunaga   Hiroshi Shirasawa   Hideo Yoshida   
Pediatric surgery international   36(10) 1173-1180   Oct 2020
PURPOSE: Oncolytic viral therapy for neuroblastoma (NB) cells with Sindbis virus (SINV) is a promising strategy for treating high-risk NB. Here, we evaluated the possibility of using SINV structural proteins as therapeutic agents for NB since UV-i...

Misc.

<23456>
 
 
The association between DEPDC5 polymorphism and the development of hepatocellular carcinoma in patients with chronic hepatitis C
Shingo Nakamoto   Tatsuo Kanda   Shuang Wu   Xia Jiang   Tatsuo Miyamura   Makoto Arai   Keiichi Fujiwara   Kengo Saito   Fumio Imazeki   Hiroshi Shirasawa   Osamu Yokosuka   
HEPATOLOGY   56 668A-669A   Oct 2012   
 
C型慢性肝疾患の肝発癌予測における遺伝子多型の有用性に関する検討
中本 晋吾   今関 文夫   神田 達郎   呉 霜   宮村 達雄   太和田 暁之   新井 誠人   藤原 慶一   齋藤 謙悟   白澤 浩   横須賀 收   
肝臓   53(Suppl.1) A546-A546   Apr 2012   
 
アスコルビン酸誘導体/DSPE-PEG複合体の構造と細胞障害性
森部久仁一   壬生総子   齋藤謙悟   ワリー リムウィクラン   東顕二郎   白澤浩   山本恵司   
日本DDS学会学術集会プログラム予稿集   28th 177-177   2012
 
IL28B POLYMORPHISM IS NOT ASSOCIATED WITH DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CHRONIC HEPATITIS C IN JAPAN
Shingo Nakamoto   Fumio Imazeki   Tatsuo Kanda   Shuang Wu   Tatsuo Miyamura   Akinobu Tawada   Makoto Arai   Keiichi Fujiwara   Kengo Saito   Hiroshi Shirasawa   Osamu Yokosuka   
HEPATOLOGY   54 1183A-1184A   Oct 2011   
 
C型慢性肝炎におけるPEG-IFN、RBV併用療法の治療効果予測
中本 晋吾   今関 文夫   神田 達郎   呉 霜   宮村 達雄   太和田 暁之   三方 林太郎   多田 素久   千葉 哲博   新井 誠人   藤原 慶一   金井 文彦   元 精華   齋藤 謙悟   白澤 浩   横須賀 收   
日本消化器病学会雑誌   108(臨増大会) A933-A933   Sep 2011   

Professional Memberships

12>
 
 
   
 
American Society for Virology
 
   
 
American Society for Microbiology
 
   
 
分子生物学会
 
   
 
日本産科婦人科学会
 
   
 
日本癌学会

Works

 
 
 

Research Projects

12345>
 
 
免疫チェックポイント阻害剤に耐性を示す口腔癌に対する腫瘍溶解ウイルス療法の新戦略
日本学術振興会: 科学研究費助成事業
齋藤 謙悟 白澤 浩 
Project Year: Apr 2020 - Mar 2023
 
Development of highly functional molecular target drug that enables clinical practice of malignant melanoma using combined immunotherapy
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
SUGANAMI Akiko Kumar P. K. R. 
Project Year: Apr 2016 - Mar 2019
 
Development of oncolytic RNA virus sensitive to ganciclovir
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
SHIRASAWA Hiroshi 
Project Year: Apr 2014 - Mar 2017
 
Development of a molecular-targeting therapeutic agent for cancer therapy using a cancer-targeting liposome coupled with viral proteins
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
TANZAWA HIDEKI SHIRASAWA Hiroshi SAITO Kengo 
Project Year: Apr 2011 - Mar 2014
 
Establishment of a novel therapeutic approach targeting cancer stem cells of neuroblastoma using onclytic virus
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
YOSHIDA Hideo HISHIKI Tomoro KAMIJO Takehiko SHIRASAWA Hiroshi SAITO Takeshi 
Project Year: 2010 - 2012
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