大学院医学研究院

研究キーワード

ウイルス分子生物学 Molecular Biology Cancer Studies ,Molecular Biology Cancer Studies

研究分野

ライフサイエンス / ウイルス学 /

論文

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Hepatitis B Virus Genotype C is Predominant in Myanmar

Nan Nwe Win Shingo Nakamoto Myint Myint Sein Mitsuhiko Moriyama Tatsuo Kanda Hiroshi Shirasawa

Diseases 6(1) 3-3 2017年12月 [査読有り]

Myanmar is adjacent to India, Bangladesh, Thailand, Laos and China. In Myanmar, the prevalence of hepatitis B virus (HBV) infections is 6.5% and accounts for 60% of hepatocellular carcinoma. HBV has nine genotypes that have been identified by mole...

Glucose-regulated protein 78 is an antiviral against hepatitis a virus replication

Xia Jiang Tatsuo Kanda Yuki Haga Reina Sasaki Masato Nakamura Shuang Wu Shingo Nakamoto Hiroshi Shirasawa Hiroaki Okamoto Osamu Yokosuka

Experimental and Therapeutic Medicine 13(6) 3305-3308 2017年6月 [査読有り]

Infection with hepatitis A virus (HAV) is a major cause of acute hepatitis globally and it is important to identify the mechanisms of HAV replication. Glucose-regulated protein 78 (GRP78) is an endoplasmic reticulum (ER) chaperone and serves a rol...

Feasibility of viral dust infection via air movement and dispersion of dried viral particles from the floor

Kohji Mori Aya Onuki Fumio Kanou Tetsuya Akiba Yukinao Hayashi Hiroshi Shirasawa Kenji Sadamasu

Journal of Medical Virology 89(5) 931-935 2017年5月 [査読有り]

The contributions of splash from vomiting and the dispersion of dried-up virus from a contaminated floor surface to community gastroenteritis outbreaks caused by Norovirus (NoV) were evaluated, using Feline calicivirus (FCV) as an NoV surrogate. T...

Free fatty acids or high-concentration glucose enhances hepatitis A virus replication in association with a reduction in glucose-regulated protein 78 expression

Nan Nwe Win Tatsuo Kanda Masato Nakamura Shingo Nakamoto Hiroaki Okamoto Osamu Yokosuka Hiroshi Shirasawa

Biochemical and Biophysical Research Communications 483(1) 694-699 2017年1月 [査読有り]

Although the interaction between host and hepatitis A virus (HAV) factors could lead to severe hepatitis A, the exact mechanism of acute liver failure caused by HAV infection is not yet fully understood. The effects of metabolic diseases such as d...

Association of IFNL3 Genotype with Hepatic Steatosis in Chronic Hepatitis C Patients Treated with Peginterferon and Ribavirin Combination Therapy

Shingo Nakamoto Fumio Imazeki Tatsuo Kanda Shuang Wu Masato Nakamura Shin Yasui Akinobu Tawada Rintaro Mikata Tetsuhiro Chiba Makoto Arai Osamu Yokosuka Hiroshi Shirasawa

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 14(11) 1088-1093 2017年 [査読有り]

Background: Genetic variation near the interferon lambda 3 (IFNL3) is known to be associated with response to pegylated interferon (pegIFN) and ribavirin combination therapy in patients with chronic hepatitis C virus (HCV) infection which is often...