Yasushi Yoshida   Hidetoshi Ida   Takashi Mino   Masami Sakamoto   
Molecules 28(11) 2023年6月
1,2,4-Triazole and 1,2,4-triazoline are important components of bioactive molecules and catalysts employed in organic synthesis. Therefore, the efficient synthesis of these components has received significant research attention. However, studies o...
Takashi Mino   Kaho Takaya   Kaito Koki   Natsume Akimoto   Yasushi Yoshida   Yoshio Kasashima   Masami Sakamoto   
Organic and Biomolecular Chemistry 2023年
We synthesized N-alkyl-N-cinnamoyl amide type phosphine-olefin compounds 1 and found axial chirality in a C(aryl)-N(amide) bond in compounds 1 by HPLC analysis using a chiral stationary phase column. We successfully obtained enantiomeric isomers o...
Takashi Mino   Kaho Takaya   Kaito Koki   Natsume Akimoto   Yasushi Yoshida   Yoshio Kasashima   Masami Sakamoto   
Organic & Biomolecular Chemistry 21(13) 2775-2778 2023年
We synthesized cinnamoyl amide type compounds 1 with axial chirality. We demonstrated the use of (–)-1 for chiral ligands in Pd-catalyzed asymmetric allylic substitution reactions of allylic esters with indoles (up to 97% ee).