Aberrant differentiation of progenitor cells in the hematopoietic system is known to severely impact host immune responsiveness. Here we demonstrate that NOD1, a cytosolic innate sensor of bacterial peptidoglycan, also functions in murine hematopo...
Metabolic fluxes involving fatty acid biosynthesis play essential roles in controlling the differentiation of T helper 17 (T H 17) cells. However, the exact enzymes and lipid metabolites involved, as well as their link to promoting the ...
Journal of diabetes investigation 14(9) 1136-1139 2023年6月
Psoriasis is a chronic inflammatory skin disease that is associated with obesity and myocardial infarction. Obesity-induced changes in lipid metabolism promote T helper 17 (Th17) cell differentiation, which in turn promotes chronic inflammation. T...
Ryo Koyama-Nasu   Motoko Y. Kimura   Masahiro Kiuchi   Ami Aoki   Yangsong Wang   Yukiyoshi Mita   Ichita Hasegawa   Yukihiro Endo   Atsushi Onodera   Kiyoshi Hirahara   Shinichiro Motohashi   Toshinori Nakayama   
Cancer Immunology Research in press(8) 1085-1099 2023年5月 [査読有り]
Abstract
Tumor-specific CD8+ T cells play a pivotal role in anti-tumor immunity and are a key target of immunotherapeutic approaches. Intratumoral CD8+ T cells are heterogeneous; Tcf1+ stem-like CD8+ T cells give rise to their cytotoxic progeny ...